{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T14:48:44Z","timestamp":1708613324383},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec><jats:label \/><jats:p>Diabet. Med. 29, 351\u2013358 (2012)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> Women with former gestational diabetes are at increased risk of Type\u20032 diabetes, which likely relates to hyperlipidaemia and ectopic lipid storage, mainly in the liver. Here, we examined the response of non\u2010esterified fatty acid dynamics to oral glucose loading (oral glucose tolerance test).<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> We studied women with former gestational diabetes with normal glucose tolerance (<jats:italic>n<\/jats:italic>\u2003=\u200360) or impaired glucose metabolism (<jats:italic>n<\/jats:italic>\u2003=\u200312) and compared them with healthy women after normal pregnancy (control subjects, <jats:italic>n<\/jats:italic>\u2003=\u200315). During a 3\u2010h oral glucose tolerance test, glucose, insulin and non\u2010esterified fatty acid were frequently measured to compute the area under the non\u2010esterified fatty acid curve and parameters of \u03b2\u2010cell function and insulin sensitivity. Through mathematical modelling, we assessed insulin sensitivity of lipolysis inhibition and the fractional non\u2010esterified fatty acid turnover rate. We also measured some serum liver enzymes.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Women with former gestational diabetes were slightly older and had greater body mass than control subjects. Subjects with impaired glucose metabolism had lower oral glucose insulin sensitivity, but higher fasting insulin and area under the non\u2010esterified fatty acid curve, which inversely related to oral glucose insulin sensitivity and independently determined mean glycaemia. Model\u2010derived non\u2010esterified fatty acid parameters were lower in subjects with impaired glucose metabolism than in control subjects, particularly sensitivity of non\u2010esterified fatty acid inhibition to insulin (2.50\u2003\u00b1\u20030.52 vs. 1.06\u2003\u00b1\u20030.20\u00b710<jats:sup>\u22122<\/jats:sup>\u2003ml\/\u03bcU). Also, subjects with impaired glucose metabolism had higher liver transaminases. However, all non\u2010esterified fatty acid parameters showed only modest inverse correlation with liver transaminases.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Despite greater insulinaemia, circulating non\u2010esterified fatty acids are higher in women with former gestational diabetes than in control subjects, which likely results from reduced sensitivity of lipolysis inhibition to insulin. This parameter may serve as indicator of an early metabolic derangement in this population at risk for diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2011.03477.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T17:58:11Z","timestamp":1318355891000},"page":"351-358","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Non\u2010esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Tura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Winhofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Di 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