{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:40:32Z","timestamp":1790120432380,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Diabet. Med. 29, 609\u2013613 (2012)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Aims\u2002<\/jats:bold>\n                      This study investigated dynamic cerebral autoregulation in Type\u20032 diabetes, where dynamic cerebral autoregulation may be impaired as a consequence of microvascular changes and\/or autonomic neuropathy.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Methods\u2002<\/jats:bold>\n                      Eleven healthy control subjects and 11 age\u2010 and sex\u2010matched patients with Type\u20032 diabetes controlled with lifestyle modifications or oral anti\u2010diabetes treatment were recruited. Dynamic cerebral autoregulation was calculated by the autoregressive moving average autoregulatory index from a continuous blood pressure and R\u2010R interval (time between each ventricular systole) recording. End\u2010tidal carbon dioxide was also monitored and changes in response to breath holding and hyperventilation as a metabolic stimulus were measured.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Results\u2002<\/jats:bold>\n                      No significant differences were seen in cerebral blood flow velocity at baseline, or in response to breath holding between people with diabetes and control subjects, although the cerebral blood flow velocity response associated with hyperventilation was significantly reduced in the diabetes group. No significant differences in dynamic cerebral autoregulation were seen at baseline or in response to respiratory manoeuvres between the groups.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusions\u2002<\/jats:bold>\n                      Dynamic cerebral autoregulation is not impaired in patients with Type\u20032 diabetes, although a small difference could not be excluded as the study was only powered to detect an autoregulatory index difference &gt;\u20032 units. Further study in a larger population with a spectrum of disease severity may reveal clinically important differences.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-5491.2011.03497.x","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T12:12:39Z","timestamp":1318853559000},"page":"609-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dynamic cerebral autoregulation assessed by respiratory manoeuvres in non\u2010insulin\u2010treated Type 2 diabetes mellitus"],"prefix":"10.1111","volume":"29","author":[{"given":"R.","family":"Huq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Philbey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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