{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:46:14Z","timestamp":1787611574489,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Diabet. Med. 29, 614\u2013621 (2012)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2002<\/jats:bold> Progressive decline in renal function has been well described in patients with Type\u20032 diabetes mellitus, but few studies have assessed the risk of acute renal failure in a large population of patients with Type\u20032 diabetes. This study quantified the risk of acute renal failure associated with Type\u20032 diabetes in the General Practice Research Database from the UK.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Patients with Type\u20032 diabetes (<jats:italic>n<\/jats:italic>\u2003=\u2003119\u2003966) and patients without diabetes (<jats:italic>n<\/jats:italic>\u2003=\u20031\u2003794\u2003516) were identified in the General Practice Research Database. Patients with end\u2010stage renal disease were excluded. Crude incidence and multivariate\u2010adjusted hazard ratios of acute renal failure were estimated for patients with diabetes relative to those without diabetes. Cox regression models were adjusted for a variety of comorbidities. Increase of acute renal failure risk resulting from additive effects of specific co\u2010morbidities with Type\u20032 diabetes was also assessed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Between 2003 and 2007, acute renal failure incidence was 198 per 100\u2003000 person\u2010years in patients with Type\u20032 diabetes compared with 27 per 100\u2003000 patients\u2010years among patients without diabetes (crude hazard ratio 8.0, 95%\u2003CI 7.4\u20138.7). Risk of acute renal failure for patients with Type\u20032 diabetes remained significant, but was attenuated in multivariate analyses adjusting for various comorbidities (adjusted hazard ratio 2.5, 95%\u2003CI 2.2\u20132.7). Age and specific comorbidities (chronic kidney disease, hypertension and congestive heart failure) were also associated with increased risk of acute renal failure in Type\u20032 diabetes.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Patients with Type\u20032 diabetes have increased risk for acute renal failure compared with patients without diabetes, even after adjustment for known risk factors, particularly in the elderly and those with other comorbidities such as chronic kidney disease, congestive heart failure and hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2011.03498.x","type":"journal-article","created":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T12:25:06Z","timestamp":1319199906000},"page":"614-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Risk of acute renal failure in patients with Type\u20032 diabetes mellitus"],"prefix":"10.1111","volume":"29","author":[{"given":"C. J.","family":"Girman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. D.","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Brodovicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. E.","family":"Williams\u2010Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0218"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032401"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi296"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070756"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318168c590"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81128-0"},{"key":"e_1_2_7_8_2","volume-title":"Annual Data Report: Atlas of Chronic Kidney Disease and End\u2010Stage Renal Disease in the United States","author":"US Renal Data System (USRDS)","year":"2009"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005060668"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.01.069"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.08.039"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000099012"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.107"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007080837"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181979440"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02610607"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04248-7"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9025"},{"key":"e_1_2_7_19_2","first-page":"i","article-title":"Obesity: preventing and managing the global epidemic. Report of a WHO consultation","volume":"894","author":"WHO","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-11-1"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmi026"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.005"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100409"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4101.096153"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02541.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90181-4"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3879"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010073"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2005.00482.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.04.029"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2011.03498.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2011.03498.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:32:58Z","timestamp":1698733978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2011.03498.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,16]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1464-5491.2011.03498.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2011.03498.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,16]]},"assertion":[{"value":"2012-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}