{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:59:02Z","timestamp":1697536742021},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:label \/><jats:p>Diabet. Med. 29, e117\u2013e120 (2012)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction\u2002<\/jats:bold> Circulating pigment epithelium\u2010derived factor, or serine protease inhibitor F1, is upregulated during adipogenesis, contributing to obesity\u2010induced insulin resistance. Furthermore, pigment epithelium\u2010derived factor is abundant in stage I melanosomes and has been reported to increase pigment granules and the appearance of mature melanosomes in retinal pigment epithelium. As acanthosis nigricans is a well\u2010recognized clinical marker of insulin resistance, we hypothesized that increased pigment epithelium\u2010derived factor might be associated with the generation of acanthosis nigricans.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Acanthosis nigricans, anthropometric measurements, circulating total PEDF and metabolic profiles were assessed in 28 obese adolescents in a hospital\u2010based obesity clinic.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Subjects with acanthosis nigricans (<jats:italic>n<\/jats:italic>\u2003=\u200310) showed greater plasma levels of pigment epithelium\u2010derived factor (PEDF) than those without [geometric mean 23.55 (range 15.2\u201340.2) vs. 9.01 (range 5.5\u201318.7) \u03bcg\/ml; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001]. Although pigment epithelium\u2010derived factor was positively correlated with the homeostasis model assessment for insulin resistance (HOMA\u2010IR) (<jats:italic>r<\/jats:italic>\u2003=\u20030.779, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001; 95% CI 0.573\u20130.892), as previously reported, for the same degree of insulin resistance, those with acanthosis nigricans exhibited a 2.1\u2010fold (95%CI 2.0\u20132.3) higher level of pigment epithelium\u2010derived factor.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> While acanthosis nigricans is undoubtedly associated with insulin resistance, its appearance is not ubiquitous in patients at any given level of HOMA\u2010IR. The higher levels of pigment epithelium\u2010derived factor in those with acanthosis nigricans compared with those without, with similar levels of resistance, suggest that pigment epithelium\u2010derived factor levels are associated with acanthosis nigricans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2012.03592.x","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T20:13:11Z","timestamp":1327954391000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum levels of pigment epithelium\u2010derived factor <b>(<\/b>PEDF<b>)<\/b> are positively associated with acanthosis nigricans in obese adolescents"],"prefix":"10.1111","volume":"29","author":[{"given":"J.","family":"Galhardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. P.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P. H.","family":"Shield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(91)90248-D"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22072"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.212"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.06.001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.6.1009"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.016"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.083485"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112657"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr060363j"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(98)00014-8"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2887"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2140"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12462293"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/EDR.2003.205"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","DOI":"10.5070\/D37MF6G290","article-title":"Acanthosis nigricans: a practical approach to evaluation and management","volume":"14","author":"Higgins SP","year":"2008","journal-title":"Dermatol Online J"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0630"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02281.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728220903241641"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.01.019"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2012.03592.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2012.03592.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2012.03592.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:40:14Z","timestamp":1697452814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2012.03592.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,19]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1464-5491.2012.03592.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2012.03592.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,19]]},"assertion":[{"value":"2012-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}