{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:51:31Z","timestamp":1781596291001,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T00:00:00Z","timestamp":1344816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Diabet. Med. 29, e286\u2010e289 (2012)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2002<\/jats:bold> To determine the incidence of coeliac disease in young people with Type\u20031 diabetes and to examine the effect of age at diabetes onset and disease duration.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This was a clinic\u2010based observational cohort study of 4379 people aged \u2264\u200318\u2003years (49% male) between 1990 and 2009 from Sydney, Australia. Screening for coeliac disease was performed at diagnosis and 1\u20132\u2003yearly using anti\u2010endomysial and\/or anti\u2010tissue transglutaminase immunoglobulin\u2003A (IgA) antibodies. Coeliac disease was diagnosed by small bowel biopsy based on Marsh score \u2265\u2003III.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Coeliac disease was confirmed by biopsy in 185; of these, 61 (33%) were endomysial or tissue transglutaminase IgA antibody\u2010positive at diabetes diagnosis. Mean age at diabetes onset was 6.6\u2003\u00b1\u20034.0 vs. 8.4\u2003\u00b1\u20034.1\u2003years in those without coeliac disease (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Mean incidence was 7.7 per 1000 person years (95%\u2003CI 6.6\u20138.9) over 20\u2003years. Incidence was higher in children aged &lt;\u20035\u2003years at diabetes diagnosis (10.4 per 1000 person years) vs. \u2265\u20035\u2003years (6.4 per 1000), incidence rate ratio 1.6 (95%\u2003CI 1.2\u20132.2, <jats:italic>P<\/jats:italic>\u2003=\u20030.002). Coeliac disease was diagnosed after 2, 5 and 10\u2003years of diabetes in 45, 78 and 94% of cases, respectively. Median time to coeliac disease diagnosis was longer in children aged &lt;\u20035\u2003years at diabetes onset (3.3\u2003years) compared with older children (0.7\u2003years, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Coeliac disease is common in young people with Type\u20031 diabetes; the risk is greatest with diabetes onset &lt;\u20035\u2003years, but after longer diabetes duration. Screening for coeliac disease should be performed at diabetes diagnosis and for at least 10\u2003years in young children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2012.03720.x","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T19:00:58Z","timestamp":1338922858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Coeliac disease in Type\u20031 diabetes from 1990 to 2009: higher incidence in young children after longer diabetes duration"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Pham\u2010Short","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Donaghue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ambler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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