{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:20:04Z","timestamp":1782894004642,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Diabet. Med. 30, 123\u2013125 (2013)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acute tubulointerstitial nephritis, a cause of acute kidney injury, is seen occasionally following treatment with medications such as antibiotics and non\u2010steroidal anti\u2010inflammatory drugs. To date, the development of biopsy\u2010proven acute tubulointerstitial nephritis after treatment with exenatide has not been reported.<\/jats:p><jats:p><jats:bold>Case report\u2002<\/jats:bold> A 58\u2010year\u2010old man was prescribed exenatide for poorly controlled Type\u20032 diabetes mellitus. He subsequently developed deterioration in kidney function, with the estimated glomerular filtration rate declining from 59 to 39\u2003ml\u2003min<jats:sup>\u22121<\/jats:sup>\u20031.73\u2003m<jats:sup>\u22122<\/jats:sup> over 2\u2003months. Despite cessation of exenatide, there was continued deterioration in estimated glomerular filtration rate to 16\u2003ml\u2003min<jats:sup>\u22121<\/jats:sup>\u20031.73\u2003m<jats:sup>\u22122<\/jats:sup>. He underwent renal biopsy and the sections showed active diffuse tubulointerstitial nephritis with infiltration of eosinophils. He was treated with prednisolone over several months with incomplete recovery in kidney function.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Acute tubulointerstitial nephritis should be suspected if there is deterioration in kidney function in a patient treated with exenatide in the absence of other causes of acute kidney injury such as dehydration or hypotension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2012.03738.x","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T06:12:23Z","timestamp":1341468743000},"page":"123-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Acute tubulointerstitial nephritis following treatment with exenatide"],"prefix":"10.1111","volume":"30","author":[{"given":"H.","family":"Nandakoban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Furlong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Flack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1499"},{"key":"e_1_2_5_3_2","volume-title":"Information for Healthcare Professionals: Reports of Altered Kidney Function in Patients using Exenatide (Marketed as Byetta)","author":"US Food and Drug Administration","year":"2009"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1309"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pdi.1493"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70196-X"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002776"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03194.x"},{"key":"e_1_2_5_9_2","first-page":"163","article-title":"Eosinophils in urine revisited","volume":"41","author":"Ruffing KA","year":"1994","journal-title":"Clin Nephrol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708475"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050418"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh485"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2012.03738.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2012.03738.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:26:42Z","timestamp":1697628402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2012.03738.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,13]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1464-5491.2012.03738.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2012.03738.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,13]]},"assertion":[{"value":"2012-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}