{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:18:49Z","timestamp":1773422329421,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T00:00:00Z","timestamp":1138320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>A procedure for the determination of <jats:italic>N<\/jats:italic>\u2010nitrosodiethanolamine (NDELA) in personal care products was evaluated in collaborative studies by member organizations of the United Kingdom's Cosmetic Toiletry and Perfumery Association (CTPA) and LGC Limited, formerly known as the Laboratory of the Government Chemist (LGC). Samples were prepared depending on the matrix of the cosmetic product: aqueous samples were prepared by diluting in water followed by solid\u2010phase extraction; emulsions, oils and solid materials were dissolved in dichloromethane and extracted with water. NDELA was separated from the sample matrix using reverse\u2010phase liquid chromatography. The <jats:italic>N<\/jats:italic>\u2010nitroso bond was cleaved by photolysis to give nitrite, which was colorimetrically quantified. The nitrite functional group reacted with sulphanilamide in an acid medium to form a diazonium ion which was then coupled with <jats:italic>N<\/jats:italic>\u2010(1\u2010naphthyl)ethylenediamine dihydrochloride according to the Griess reaction to give a purple\u2010coloured azo dye that absorbed at 540\u2003nm. Compared with other published methods for NDELA, the method described here is quick and easy to use. It has the required sensitivity and specificity, and can accurately and reliably quantify NDELA in a wide range of personal care product matrices.<\/jats:p>","DOI":"10.1111\/j.1467-2494.2006.00294.x","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T12:31:14Z","timestamp":1138365074000},"page":"21-33","source":"Crossref","is-referenced-by-count":22,"title":["A method for the determination of <i>N<\/i>\u2010nitrosodiethanolamine in personal care products \u2013 collaboratively evaluated by the CTPA Nitrosamines Working Group"],"prefix":"10.1111","volume":"28","author":[{"given":"C.","family":"Flower","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Earls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hewlins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lalljie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mavro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Small","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,27]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Human Beings","author":"International Agency for Research on Cancer","year":"1978"},{"key":"e_1_2_8_3_2","first-page":"18","article-title":"(92\/86\/EEC)","volume":"325","author":"European Commission Directive","year":"1992","journal-title":"Official J. 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