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It is currently considered an endocrine\u2010metabolic microcirculatory disorder that causes interstitial matrix alterations and structural changes in subcutaneous adipose tissue. The first step in cellulite treatment is stimulation of microcirculation and the removal of accumulated fluids and toxic elements. This can improve the interstitial matrix basal regulation, fibroblast activity and decrease interstitial oedema, with subsequent increase in lipolysis and a better oxygen and nutrition of the adipose tissue. In this paper are reported two trials aimed at evaluating clinically and instrumentally the effects of different orally administered multifunctional plant extracts\u2010based formulations in the treatment of cellulite compared with a placebo.<\/jats:p>","DOI":"10.1111\/j.1467-2494.2006.00319.x","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T13:03:21Z","timestamp":1148303001000},"page":"191-206","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of a multifunctional plant complex in the treatment of the so\u2010called \u2018cellulite\u2019: clinical and instrumental evaluation"],"prefix":"10.1111","volume":"28","author":[{"given":"F.","family":"Distante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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