{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:47:27Z","timestamp":1775742447045,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1111\/j.1467-2995.2011.00615.x","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T11:55:42Z","timestamp":1302782142000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["The effect of midazolam on the end-tidal concentration of isoflurane necessary to prevent movement in dogs"],"prefix":"10.1016","volume":"38","author":[{"given":"Reza","family":"Seddighi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M","family":"Egger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barton W","family":"Rohrbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry K","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/j.1467-2995.2011.00615.x_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2885.1992.tb01026.x","article-title":"Pharmacokinetics and preliminary observations of behavioral changes following administration of midazolam to dogs","volume":"15","author":"Court","year":"1992","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00000542-199801000-00009","article-title":"Fentanyl augments the blockade of the sympathetic response to incision (MAC-BAR) produced by desflurane and isoflurane: desflurane and isoflurane MAC-BAR without and with fentanyl","volume":"88","author":"Daniel","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1213\/01.ANE.0000078587.51622.D0","article-title":"Can determining the minimum alveolar anesthetic concentration of volatile anesthetic be used as an objective tool to assess antinociception in animals?","volume":"97","author":"Docquier","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib4","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1046\/j.1365-2885.1997.00086.x","article-title":"Comparison of halothane minimum alveolar concentration and minimum effective concentration in ponies","volume":"20","author":"Doherty","year":"1997","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib5","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/00000539-200110000-00029","article-title":"Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake","volume":"93","author":"Eger","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00000542-196511000-00010","article-title":"Minimum alveolar anesthetic concentration: a standard of anesthetic potency","volume":"26","author":"Eger","year":"1965","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/bja\/68.1.81","article-title":"MAC-awake of isoflurane, enflurane and halothane evaluated by slow and fast alveolar washout","volume":"68","author":"Gaumann","year":"1992","journal-title":"Br J Anaesth"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/bja\/ael239","article-title":"Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats","volume":"97","author":"Grasshoff","year":"2006","journal-title":"Br J Anaesth"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1532-950X.1993.tb00373.x","article-title":"Thiamylal-sparing effect of midazolam for canine endotracheal intubation. A clinical study of 118 dogs","volume":"22","author":"Greene","year":"1993","journal-title":"Vet Surg"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/00000542-198806000-00005","article-title":"The anesthetic efficacy of midazolam in the enflurane-anesthetized dog","volume":"68","author":"Hall","year":"1988","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF01062136","article-title":"Pharmacokinetics and pharmacodynamics of midazolam in the enflurane-anesthetized dog","volume":"16","author":"Hall","year":"1988","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1213\/00000539-199303000-00029","article-title":"Anesthetic interaction between midazolam and halothane in humans","volume":"76","author":"Inagaki","year":"1993","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib13","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1097\/00000542-199412000-00024","article-title":"Anesthetic depression of spinal motor neurons may contribute to lack of movement in response to noxious stimuli","volume":"81","author":"King","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00000542-200602000-00020","article-title":"Actions of midazolam on excitatory transmission in dorsal horn neurons of adult rat spinal cord","volume":"104","author":"Kohno","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0304-3959(99)00298-5","article-title":"Effects of midazolam in the spinal nerve ligation model of neuropathic pain in rats","volume":"85","author":"Kontinen","year":"2000","journal-title":"Pain"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00000542-196305000-00016","article-title":"A comparative study of halothane and halopropane anesthesia including method for determining equipotency","volume":"24","author":"Merkel","year":"1963","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib19","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2460\/ajvr.2003.64.1155","article-title":"Effects of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine drug combination on minimum alveolar concentration in dogs anesthetized with isoflurane","volume":"64","author":"Muir","year":"2003","journal-title":"Am J Vet Res"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib20","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/BF03022529","article-title":"Analgesic effects of systemic midazolam: comparison with intrathecal administration","volume":"53","author":"Nishiyama","year":"2006","journal-title":"Can J Anaesth"},{"issue":"Suppl. 1","key":"10.1111\/j.1467-2995.2011.00615.x_bib21","first-page":"17S","article-title":"Preclinical pharmacology of midazolam","volume":"16","author":"Pieri","year":"1983","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00000542-198010000-00008","article-title":"Determination and applications of MAC","volume":"53","author":"Quasha","year":"1980","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/328221a0","article-title":"Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family","volume":"328","author":"Schofield","year":"1987","journal-title":"Nature"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2460\/ajvr.67.1.21","article-title":"Effect of intravenous administration of ketamine on the minimum alveolar concentration of isoflurane in anesthetized dogs","volume":"67","author":"Solano","year":"2006","journal-title":"Am J Vet Res"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib25","series-title":"Pharmacology & Physiology in Anesthetic Practice","first-page":"140","article-title":"Benzodiazepines","author":"Stoelting","year":"2006"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib26","series-title":"Pharmacology and Physiology in Anesthetic Practice","first-page":"33","article-title":"Pharmacokinetics and Pharmacodynamics of Injected and Inhaled Drugs","author":"Stoelting","year":"2006"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib27","first-page":"58","article-title":"Intravenous midazolam suppresses noxiously evoked activity of spinal wide dynamic range neurons in cats","volume":"80","author":"Sumida","year":"1995","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00003643-199903000-00007","article-title":"Minimum alveolar concentration of sevoflurane that blocks the adrenergic response to surgical incision in women: MACBAR","volume":"16","author":"Ura","year":"1999","journal-title":"Eur J Anaesthesiol"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib29","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2460\/ajvr.2003.64.957","article-title":"Validation of several types of noxious stimuli for use in determining the minimum alveolar concentration for inhalation anesthetics in dogs and rabbits","volume":"64","author":"Valverde","year":"2003","journal-title":"Am J Vet Res"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00000542-200502000-00021","article-title":"Action of isoflurane on the substantia gelatinosa neurons of the adult rat spinal cord","volume":"102","author":"Wakai","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib31","series-title":"Determination of MAC and MAC derivatives for isoflurane and sevoflurane in dogs","first-page":"847","author":"Wilson","year":"2008"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1467-2995.2007.00389.x","article-title":"Effects of intravenous lidocaine, ketamine, and the combination on the minimum alveolar concentration of sevoflurane in dogs","volume":"35","author":"Wilson","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0028-3908(90)90094-8","article-title":"Interaction of midazolam and morphine in the spinal cord of the rat","volume":"29","author":"Yanez","year":"1990","journal-title":"Neuropharmacology"},{"key":"10.1111\/j.1467-2995.2011.00615.x_bib34","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1213\/ane.0b013e3181732ee3","article-title":"The effects of aromatic anesthetics on dorsal horn neuronal responses to noxious stimulation","volume":"106","author":"Yao","year":"2008","journal-title":"Anesth Analg"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716306493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716306493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:53:11Z","timestamp":1761447191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298716306493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S1467298716306493"],"URL":"https:\/\/doi.org\/10.1111\/j.1467-2995.2011.00615.x","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of midazolam on the end-tidal concentration of isoflurane necessary to prevent movement in dogs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1467-2995.2011.00615.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}