{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T02:47:53Z","timestamp":1786762073026,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1111\/j.1467-2995.2011.00619.x","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T06:40:09Z","timestamp":1307342409000},"page":"320-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats"],"prefix":"10.1016","volume":"38","author":[{"given":"Luiz Cesar P","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Ludders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hollis N","family":"Erb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Martin-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Basher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pati","family":"Kirch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1467-2995.2011.00619.x_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000087979","article-title":"5-HT3-receptor antagonists in the management of nausea and vomiting in cancer and cancer treatment","volume":"69","author":"Aapro","year":"2005","journal-title":"Oncology"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib2","series-title":"Use of the Alpha-2-Adrenoceptor Agonists Medetomidine and Dexmedetomidine in the Sedation and Analgesia of Domestic Cats","author":"Ansah","year":"2004"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1046\/j.1365-2885.1998.00155.x","article-title":"Comparison of three doses of dexmedetomidine with medetomidine in cats following intramuscular administration","volume":"21","author":"Ansah","year":"1998","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0028-3908(88)90092-5","article-title":"Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret","volume":"27","author":"Barnes","year":"1988","journal-title":"Neuropharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0361-9230(86)90004-3","article-title":"Dimethylphenylpiperazinium-induced vomiting: nicotinic mediation in area postrema","volume":"16","author":"Beleslin","year":"1986","journal-title":"Brain Res Bull"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/0028-3908(87)90262-0","article-title":"Noradrenaline-induced emesis. Alpha-2 adrenoceptor mediation in the area postrema","volume":"26","author":"Beleslin","year":"1987","journal-title":"Neuropharmacology"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1213\/00000539-199109000-00003","article-title":"Antiemetic efficacy of ondansetron after outpatient laparoscopy","volume":"73","author":"Bodner","year":"1991","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1476-5381.1988.tb11542.x","article-title":"Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors","volume":"94","author":"Butler","year":"1988","journal-title":"Br J Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2346.1999.00547.x","article-title":"Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients","volume":"16","author":"Chung","year":"1999","journal-title":"Eur J Anaesthesiol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib10","first-page":"33","article-title":"5-HT3-receptor antagonists: a review of pharmacology and clinical efficacy","volume":"24","author":"Cunningham","year":"1997","journal-title":"Oncol Nurs Forum"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib11","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1213\/01.ane.0000263277.35140.a3","article-title":"A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting","volume":"104","author":"Gan","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4037\/ccn2003.23.1.31","article-title":"Managing nausea and vomiting. Current strategies","volume":"23","author":"Garrett","year":"2003","journal-title":"Crit Care Nurs"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1467-2995.2005.00259.x","article-title":"Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole","volume":"33","author":"Granholm","year":"2006","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1476-5381.1989.tb11948.x","article-title":"5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret","volume":"97","author":"Higgins","year":"1989","journal-title":"Br J Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib15","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.2460\/ajvr.1989.50.08.1348","article-title":"Evidence for the involvement of alpha 2-adrenoceptors in the emetic action of xylazine in cats","volume":"50","author":"Hikasa","year":"1989","journal-title":"Am J Vet Res"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-2999(92)90562-I","article-title":"Central alpha-adrenoceptor subtypes involved in the emetic pathway in cats","volume":"229","author":"Hikasa","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib17","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0022-3565(25)11100-2","article-title":"Alpha adrenoceptor subtypes involved in the emetic action in dogs","volume":"261","author":"Hikasa","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib18","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.2460\/ajvr.2001.62.1218","article-title":"Effects of dexamethasone on emesis in cats sedated with xylazine hydrochloride","volume":"62","author":"Ho","year":"2001","journal-title":"Am J Vet Res"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s002800051014","article-title":"Nasal absorption of ondansetron in rats: an alternative route of drug delivery","volume":"45","author":"Hussain","year":"2000","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib20","first-page":"287","article-title":"Human pharmacology of narcotic antagonists","volume":"7","author":"Jasinski","year":"1978","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3565(24)39196-7","article-title":"In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors","volume":"293","author":"Kable","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib22","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1073\/pnas.94.18.9950","article-title":"Substitution of a mutant alpha2a-adrenergic receptor via \u2018hit and run\u2019 gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo","volume":"94","author":"Lakhlani","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1213\/00000539-199109000-00002","article-title":"Treatment of postoperative nausea and vomiting with ondansetron: a randomized, double-blind comparison with placebo","volume":"73","author":"Larijani","year":"1991","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0091-3057(89)90235-9","article-title":"Blockade of 5-hydroxytryptamine3 receptors prevents cisplatin-induced but not motion- or xylazine-induced emesis in the cat","volume":"32","author":"Lucot","year":"1989","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib25","series-title":"Small Animal Clinical Pharmacology","first-page":"434","author":"Maddison","year":"2008"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jfms.2008.12.008","article-title":"Evaluation of cardiorespiratory effects of combinations of dexmedetomidine and atropine in cats","volume":"11","author":"Monteiro","year":"2009","journal-title":"J Feline Med Surg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib27","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/00000542-199412000-00029","article-title":"Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat","volume":"81","author":"Nacif-Coelho","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib28","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1136\/vr.153.15.462","article-title":"Changes in thermal threshold response in eight cats after administration of buprenorphine, butorphanol and morphine","volume":"153","author":"Robertson","year":"2003","journal-title":"Vet Rec"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/vr.152.22.675","article-title":"Systemic uptake of buprenorphine by cats after oral mucosal administration","volume":"152","author":"Robertson","year":"2003","journal-title":"Vet Rec"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jfms.2003.10.002","article-title":"Pain management in cats \u2013 past, present and future. Part II. Treatment of pain \u2013 clinical pharmacology","volume":"6","author":"Robertson","year":"2004","journal-title":"J Feline Med Surg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib31","first-page":"453","article-title":"PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration","volume":"28","author":"Robertson","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-2999(00)00061-3","article-title":"Cisplatin-induced emesis in the cat: effect of granisetron and dexamethasone","volume":"391","author":"Rudd","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib33","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1213\/00000539-199704000-00025","article-title":"Intravenous ondansetron for post-surgical opioid-induced nausea and vomiting","volume":"84","author":"Rung","year":"1997","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib34","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1467-2995.2010.00555.x","article-title":"Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes","volume":"37","author":"Santos","year":"2010","journal-title":"Vet Anaesh Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib35","series-title":"Anesthetic Pharmacology: Physiologic Principles and Clinical Practice: a Companion to Miller\u2019s Anesthesia","first-page":"777","article-title":"Antiemetics","author":"Scholz","year":"2004"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib36","series-title":"The handbook of nausea and vomiting","first-page":"106","article-title":"Preventing Postoperative Nausea and Vomiting","author":"Sleisenger","year":"1993"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jfms.2009.03.009","article-title":"Thermal antinociception after dexmedetomidine administration in cats: a comparison between intramuscular and oral transmucosal administration","volume":"11","author":"Slingsby","year":"2009","journal-title":"J Feline Med Surg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib38","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1213\/00000539-199710000-00015","article-title":"A comparison of the prophylactic antiemetic effect of ondansetron and droperidol on patients undergoing gynecological laparoscopy","volume":"85","author":"Sniadach","year":"1997","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib39","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.2042-7158.1996.tb03973.x","article-title":"Clinical pharmacokinetics of ondansetron: a review","volume":"48","author":"Simpson","year":"1996","journal-title":"J Pharm Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1213\/00000539-199702000-00016","article-title":"The effect of timing of ondansetron administration in outpatients undergoing otolaryngologic surgery","volume":"84","author":"Sun","year":"1997","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib41","first-page":"391","article-title":"Morphine, pethidine and buprenorphine disposition in the cat","volume":"24","author":"Taylor","year":"2001","journal-title":"J Pharm Pharmacol"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib42","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1046\/j.1365-2648.1999.00998.x","article-title":"The management of post-operative nausea and vomiting","volume":"29","author":"Thompson","year":"1999","journal-title":"J Adv Nurs"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/BF03548031","article-title":"Clinical evaluation of medetomidine, a novel sedative and analgesic drug for dogs and cats","volume":"30","author":"V\u00e4h\u00e4-Vahe","year":"1989","journal-title":"Acta Vet Scand"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib44","first-page":"53","article-title":"Medetomidine, a new sedative and analgesic drug for dogs and cats","volume":"14","author":"Vainio","year":"1986","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib45","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2460\/javma.1998.213.02.243","article-title":"Comparison of four regimens for intraoral administration of medication to induce sedation in cats prior to euthanasia","volume":"213","author":"Wetzel","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib46","series-title":"Dealing with Vomiting that cannot be Stopped","author":"Willard","year":"1999"},{"key":"10.1111\/j.1467-2995.2011.00619.x_bib47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1527-3458.2001.tb00195.x","article-title":"Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders","volume":"7","author":"Ye","year":"2001","journal-title":"CNS Drug Rev"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716306663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716306663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:54:15Z","timestamp":1761447255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298716306663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S1467298716306663"],"URL":"https:\/\/doi.org\/10.1111\/j.1467-2995.2011.00619.x","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1467-2995.2011.00619.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}