{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:27:33Z","timestamp":1778279253920,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["vaajournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Anaesthesia and Analgesia"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1111\/j.1467-2995.2012.00714.x","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T06:41:23Z","timestamp":1338360083000},"page":"472-479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diabetes mellitus affects the duration of action of vecuronium in dogs"],"prefix":"10.1016","volume":"39","author":[{"given":"Louise","family":"Clark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Leece","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline C","family":"Brearley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/j.1467-2995.2012.00714.x_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.5507\/bp.2007.051","article-title":"Influence of gender on the onset and duration of rocuronium-induced neuromuscular block","volume":"151","author":"Adamus","year":"2007","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1213\/00000539-198001000-00006","article-title":"Cardiovascular and neuromuscular effects of Org NC 45, pancuronium, metocurine, and d-tubocurarine in dogs","volume":"59","author":"Booij","year":"1980","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib3","first-page":"329","article-title":"Pharmacokinetics and pharmacodynamics of the muscle relaxant drug Org NC-45 and each of its hydroxy metabolites in dogs","volume":"30","author":"Booij","year":"1981","journal-title":"Anaesthesist"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib5","first-page":"301","article-title":"Monitoring of neuromuscular transmission by electromyography during anaesthesia. A comparison with mechanomyography in cat and man","volume":"43","author":"Engbaek","year":"1996","journal-title":"Dan Med Bull"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib6","series-title":"Canine and Feline Endocrinology and Reproduction","first-page":"495","article-title":"Canine diabetes mellitus","author":"Feldman","year":"2004"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib7","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/bja\/68.5.540","article-title":"Corticosteroids and resistance to vecuronium","volume":"68","author":"Fiacchino","year":"1992","journal-title":"Br J Anaesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib8","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/bja\/aeg617","article-title":"Monitoring neuromuscular blockade in diabetic patients using electromyography: an opportunity missed","volume":"91","author":"Hemmerling","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib9","first-page":"72","article-title":"[Measuring muscle relaxation with mivacurium in comparison with mechano- and electromyography]","volume":"23","author":"Hofmockel","year":"1998","journal-title":"Anaesthesiol Reanim"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2460\/javma.1983.183.09.1007","article-title":"Peripheral neuropathy and hypotension in a diabetic dog","volume":"183","author":"Johnson","year":"1983","journal-title":"J Am Vet Med Assoc"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0034-5288(18)31825-3","article-title":"Neuromuscular blocking action of vecuronium in the dog and its reversal by neostigmine","volume":"38","author":"Jones","year":"1985","journal-title":"Res Vet Sci"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2460\/javma.1985.187.03.281","article-title":"New skeletal muscle relaxants in dogs and cats","volume":"187","author":"Jones","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1365-2044.2005.04218.x","article-title":"Anabolic steroid abuse: physiological and anaesthetic considerations","volume":"60","author":"Kam","year":"2005","journal-title":"Anaesthesia"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1467-2995.2008.00401.x","article-title":"The effects of medetomidine on the action of vecuronium in dogs anaesthetized with halothane and nitrous oxide","volume":"35","author":"Kariman","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib15","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2460\/javma.1983.182.05.522","article-title":"Polyneuropathy associated with diabetes mellitus in a dog","volume":"182","author":"Katherman","year":"1983","journal-title":"J Am Vet Med Assoc"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-2999(92)90828-R","article-title":"Antagonism of vecuronium by one of its metabolites in vitro","volume":"222","author":"Khuenl-Brady","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1001\/archneur.1961.00450170021003","article-title":"Motor nerve conduction velocity in diabetes","volume":"5","author":"Lawrence","year":"1961","journal-title":"Arch Neurol"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1213\/00000539-197509000-00021","article-title":"Train-of-4 quantitation of competitive neuromuscular block","volume":"54","author":"Lee","year":"1975","journal-title":"Anesth Analg"},{"issue":"Suppl 1","key":"10.1111\/j.1467-2995.2012.00714.x_bib19","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1093\/bja\/52.suppl_1.11S","article-title":"Pharmacology of ORG NC 45 compared with other non-depolarizing neuromuscular blocking drugs","volume":"52","author":"Marshall","year":"1980","journal-title":"Br J Anaesth"},{"issue":"Suppl 1","key":"10.1111\/j.1467-2995.2012.00714.x_bib20","doi-asserted-by":"crossref","first-page":"21S","DOI":"10.1093\/bja\/52.suppl_1.21S","article-title":"Comparison of the cardiovascular actions of ORG NC 45 with those produced by other non-depolarizing neuromuscular blocking agents in experimental animals","volume":"52","author":"Marshall","year":"1980","journal-title":"Br J Anaesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib21","first-page":"583","article-title":"Clinical peripheral neuropathy associated with diabetes mellitus in 3 dogs","volume":"49","author":"Morgan","year":"2008","journal-title":"Can Vet J"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0952-8180(98)00006-3","article-title":"Comparison of acceleromyography and electromyography in vecuronium-induced neuromuscular blockade with xenon or sevoflurane anesthesia","volume":"10","author":"Nakata","year":"1998","journal-title":"J Clin Anesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib23","first-page":"I22","article-title":"Variable designs of clinical trials of neuromuscular blocking agents: an example of studies comparing rocuronium and vecuronium","volume":"11","author":"Nava-Ocampo","year":"2005","journal-title":"Med Sci Monit"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00125-004-1642-x","article-title":"Use of a reference four-component model to define the effects of insulin treatment on body composition in type 2 diabetes: the \u2018Darwin study\u2019","volume":"48","author":"Packianathan","year":"2005","journal-title":"Diabetologia"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/0310057X9101900120","article-title":"Betamethasone-induced resistance to vecuronium: a potential problem in neurosurgery?","volume":"19","author":"Parr","year":"1991","journal-title":"Anaesth Intensive Care"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib26","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/bja\/67.4.447","article-title":"Interaction between betamethasone and vecuronium","volume":"67","author":"Parr","year":"1991","journal-title":"Br J Anaesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib27","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/bja\/aeg089","article-title":"Monitoring of neuromuscular block after administration of vecuronium in patients with diabetes mellitus","volume":"90","author":"Saitoh","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib28","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1365-2044.2004.03833.x","article-title":"Reversal of vecuronium with neostigmine in patients with diabetes mellitus","volume":"59","author":"Saitoh","year":"2004","journal-title":"Anaesthesia"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/BF03016524","article-title":"Delayed recovery of vecuronium neuromuscular block in diabetic patients during sevoflurane anesthesia","volume":"52","author":"Saitoh","year":"2005","journal-title":"Can J Anaesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2174\/156800805774912971","article-title":"Hormonal effects on drug metabolism through the CYP system: perspectives on their potential significance in the era of pharmacogenomics","volume":"5","author":"Sarlis","year":"2005","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1467-2995.2008.00432.x","article-title":"The effect of volatile anaesthetics on the relative sensitivity of facial and distal thoraciic limb muscles to vecuronium in dogs","volume":"36","author":"Sarrafzadeh-Rezaei","year":"2009","journal-title":"Vet Anaesth Analg"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib32","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.2460\/ajvr.1981.42.12.2061","article-title":"Electrodiagnostic analysis of peripheral neuropathy in dogs with diabetes mellitus","volume":"42","author":"Steiss","year":"1981","journal-title":"Am J Vet Res"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00540-004-0239-3","article-title":"Duration of vecuronium-induced neuromuscular block can be predicted by change of skin temperature over the thenar muscles","volume":"18","author":"Suzuki","year":"2004","journal-title":"J Anesth"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2044.2005.04462.x","article-title":"Liver enzyme induction and inhibition: implications for anaesthesia","volume":"61","author":"Sweeney","year":"2006","journal-title":"Anaesthesia"},{"issue":"Suppl","key":"10.1111\/j.1467-2995.2012.00714.x_bib35","first-page":"438","article-title":"Comparison of the neuromuscular effects of SZ1676 and vecuronium in dog","volume":"78","author":"Thut","year":"1994","journal-title":"Anesth Analg"},{"key":"10.1111\/j.1467-2995.2012.00714.x_bib36","series-title":"Textbook of Veterinary Physiology","first-page":"522","article-title":"Solute reabsorption","author":"Verlander","year":"1997"}],"container-title":["Veterinary Anaesthesia and Analgesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716304184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1467298716304184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T02:52:10Z","timestamp":1761447130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1467298716304184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S1467298716304184"],"URL":"https:\/\/doi.org\/10.1111\/j.1467-2995.2012.00714.x","relation":{},"ISSN":["1467-2987"],"issn-type":[{"value":"1467-2987","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes mellitus affects the duration of action of vecuronium in dogs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Anaesthesia and Analgesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1467-2995.2012.00714.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}