{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:42:57Z","timestamp":1794084177858,"version":"4.8.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T00:00:00Z","timestamp":1171843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Biotechnology Journal"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The key regulator of salicylic acid (SA)\u2010mediated resistance, NPR1, is functionally conserved in diverse plant species, including rice (<jats:italic>Oryza sativa<\/jats:italic> L.). Investigation in depth is needed to provide an understanding of <jats:italic>NPR1<\/jats:italic>\u2010mediated resistance and a practical strategy for the improvement of disease resistance in the model crop rice. The rice genome contains five <jats:italic>NPR1<\/jats:italic>\u2010like genes. In our study, three rice homologous genes, <jats:italic>OsNPR1<\/jats:italic>\/<jats:italic>NH1<\/jats:italic>, <jats:italic>OsNPR2<\/jats:italic>\/<jats:italic>NH2<\/jats:italic> and <jats:italic>OsNPR3<\/jats:italic>, were found to be induced by rice bacterial blight <jats:italic>Xanthomonas oryzae<\/jats:italic> pv. <jats:italic>oryzae<\/jats:italic> and rice blast <jats:italic>Magnaporthe grisea<\/jats:italic>, and the defence molecules benzothiadiazole, methyl jasmonate and ethylene. We confirmed that <jats:italic>OsNPR1<\/jats:italic> is the rice orthologue by complementing the <jats:italic>Arabidopsis npr1<\/jats:italic> mutant. Over\u2010expression of <jats:italic>OsNPR1<\/jats:italic> conferred disease resistance to bacterial blight, but also enhanced herbivore susceptibility in transgenic plants. The OsNPR1\u2010green fluorescent protein (GFP) fusion protein was localized in the cytoplasm and moved into the nucleus after redox change. Mutations in its conserved cysteine residues led to the constitutive localization of OsNPR1(2CA)\u2010GFP in the nucleus and also abolished herbivore hypersensitivity in transgenic rice. Different subcellular localizations of OsNPR1 antagonistically regulated SA\u2010 and jasmonic acid (JA)\u2010responsive genes, but not SA and JA levels, indicating that OsNPR1 might mediate antagonistic cross\u2010talk between the SA\u2010 and JA\u2010dependent pathways in rice. This study demonstrates that rice has evolved an SA\u2010mediated systemic acquired resistance similar to that in Arabidopsis, and also provides a practical approach for the improvement of disease resistance without the penalty of decreased herbivore resistance in rice.<\/jats:p>","DOI":"10.1111\/j.1467-7652.2007.00243.x","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T14:42:14Z","timestamp":1171896134000},"page":"313-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":358,"title":["Functional analysis of rice <i>NPR1<\/i>\u2010like genes reveals that <i>OsNPR1<\/i>\/<i>NH1<\/i> is the rice orthologue conferring disease resistance with enhanced herbivore susceptibility\u2020"],"prefix":"10.1111","volume":"5","author":[{"given":"Yuexing","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengrong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggen","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3781"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/3869945"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81858-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6531"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.114.1.193"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02485.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-18-0511"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.2001.01070.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.010815"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6602"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.12.2.279"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.2000.00870.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.42.040803.140421"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2005.02457.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2001.14.9.1114"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3222006cm1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/143.2.973"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004380000278"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1994.6020271.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-19-0958"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.012211"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.53.100301.135207"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2001.01411.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.12.12.2339"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00016484"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","unstructured":"Li Q. 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