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So, the study of genetic disorders needs to change from the still widely held view that developmental disorders can be accounted for in terms of intact versus impaired modules, to one which takes serious account of the fact that the infant cortex passes from an initial state of high regional interconnectivity to a subsequent state of increasing specialization and localization of function. With such early interconnectivity in mind, developmental neuroscientists must consider the possibility that an early deficit in one part of the brain may have subtle effects on other parts of the developing brain, even when scores fall \u2018in the normal range\u2019. In studying developmental disorders, it is thus crucial to examine not only domains of clear\u2010cut deficit, but also domains of behavioural proficiency. Atypical epigenesis may often involve a lack of specialization and localization of brain function over developmental time, even in cases of behavioural proficiency.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1467-7687.2007.00568.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T06:01:09Z","timestamp":1166680869000},"page":"84-88","source":"Crossref","is-referenced-by-count":72,"title":["Atypical epigenesis"],"prefix":"10.1111","volume":"10","author":[{"given":"Annette","family":"Karmiloff\u2010Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Annaz D.(2006).The development of visuo\u2010spatial processing in children with autism Down syndrome and Williams syndrome.PhD thesis Birkbeck College University of London."},{"key":"e_1_2_7_3_1","first-page":"121","volume-title":"Children's language and communication: The Minnesota Symposium on Child Psychology","author":"Bates E.","year":"1979"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X00073799"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"136","article-title":"Evolution and neurology of language","volume":"10","author":"Bates E.","year":"1994","journal-title":"Discussions in Neuroscience"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892900561959"},{"key":"e_1_2_7_7_1","first-page":"23","volume-title":"Atypical cognitive deficits in developmental disorders: Implications for brain function","author":"Bellugi U.","year":"1994"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-07-02801.1993"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00299-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5401"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10027"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1999.1127"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(200022)97:2<164::AID-AJMG8>3.0.CO;2-F"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/5929.001.0001","volume-title":"Rethinking innateness: A connectionist perspective on development","author":"Elman J.L.","year":"1996"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80077-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/1130201"},{"key":"e_1_2_7_17_1","first-page":"6","article-title":"Genetic basis of grammar defect","volume":"346","author":"Gopnik M.","year":"1990","journal-title":"Nature"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200310060-00003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200108280-00021"},{"key":"e_1_2_7_20_1","first-page":"1","article-title":"The development of synapses in striate cortex of man","volume":"6","author":"Huttenlocher P.R.","year":"1987","journal-title":"Human Neurobiology"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/35081509"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/oso\/9780198528456.003.0013","volume-title":"Attention & performance XX: Functional imaging of visual cognition","author":"Johnson M.H.","year":"2004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-7687.00096"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/1579.001.0001","volume-title":"Beyond moduarity: A developmental perspective on cognitive science","author":"Karmiloff\u2010Smith A.","year":"1992"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565649709540693"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(98)01230-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/oso\/9780198568742.003.0024","volume-title":"Processes of change in brain and cognitive development. 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