{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:49:25Z","timestamp":1791967765682,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T00:00:00Z","timestamp":1159228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Sociology Health &amp; Illness"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Men and women who have a family history of breast and\/or ovarian cancer may be offered a predictive genetic test to determine whether or not they carry the family specific <jats:italic>BRCA1\/2<\/jats:italic> mutation. The sons and daughters of mutation carriers have a 50 per cent chance of inheriting a mutation, which will increase their risk of developing cancer. Little is known about at\u2010risk men's feelings about the part they play in the transmission of <jats:italic>BRCA1\/2<\/jats:italic> mutations within their families. This study investigated high risk men's responses to <jats:italic>BRCA1\/2<\/jats:italic> predictive genetic testing. Seventeen in\u2010depth interviews were undertaken with carrier (<jats:italic>n<\/jats:italic>= 5) and non\u2010carrier men (<jats:italic>n<\/jats:italic>= 12). All men described genetic testing as a familial duty. It is observed that carriers and non\u2010carriers mobilised differing explanations about their role in the aetiology of risk. It is noted that men engage in a form of narrative reconstruction in which they draw upon discourses of guilt and blame or fate and predestiny in an effort to present themselves as morally responsible or blameless. It is argued that narrative reconstruction enables these men to reconcile their genetic identity, self and family.<\/jats:p>","DOI":"10.1111\/j.1467-9566.2006.00515.x","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T10:21:01Z","timestamp":1159266061000},"page":"969-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Guilt, blame and responsibility: men's understanding of their role in the transmission of BRCA1\/2 mutations within their family"],"prefix":"10.1111","volume":"28","author":[{"given":"Nina","family":"Hallowell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Arden\u2010Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ros","family":"Eeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke","family":"Lucassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Moynihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Risk Society: towards a New Modernity.","author":"Beck U.","year":"1992"},{"issue":"13","key":"e_1_2_8_3_1","first-page":"10","article-title":"Cancer risks in BRCA2 mutation carriers","volume":"91","author":"The Breast Cancer Linkage Consortium","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01408408"},{"key":"e_1_2_8_5_1","volume-title":"Bioethics","author":"D\u2019Agincourt\u2010Canning L.","year":"2001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(92)90195-V"},{"key":"e_1_2_8_7_1","volume-title":"Public Risks and Private Dangers.","author":"Davison C.","year":"1992"},{"key":"e_1_2_8_8_1","unstructured":"Downing C.(2001)Reproductive Decision\u2010making in Families Facing the Risk for Huntington's Disease: Perceptions of Responsibility.PhD. 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