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We discuss the lessons that can be learned from the comparison as well as the challenges in each country to effective and efficient screening.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We used nationally representative data sources in the United States and the Netherlands to estimate the number of Pap smears and the cervical cancer mortality rate since 1950. The following questions are addressed: How do differences in intensity of Pap smear use between the countries translate into differences in mortality trends? Can population coverage rates (the proportion of eligible women who had a Pap smear within a specified period) explain the mortality trends better than the total intensity of Pap smear use?<\/jats:p><jats:p><jats:bold>Findings:<\/jats:bold> Even though three to four times more Pap smears per woman were conducted in the United States than in the Netherlands over a period of three decades, the two countries\u2019 mortality trends were quite similar. The five\u2010year coverage rates for women aged thirty to sixty\u2010four were quite comparable at 80 to 90 percent. Because screening in the Netherlands was limited to ages thirty to sixty, screening rates for women under thirty and over sixty were much higher in the United States. These differences had consequences for age\u2010specific mortality trends. The relatively good coverage rate in the Netherlands can be traced back to a nationwide invitation system based on municipal population registries. While both countries followed a \u201cpolicy cycle\u201d involving evidence review, surveillance of screening practices and outcomes, clinical guidelines, and reimbursement policies, the components of this cycle were more systematically linked and implemented nationwide in the Netherlands than in the United States. To a large extent, this was facilitated by a public health model of screening in the Netherlands, rather than a medical services model.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Cross\u2010country studies like ours are natural experiments that can produce insights not easily obtained from other types of study. The cervical cancer screening system in the Netherlands seems to have been as effective as the U.S. system but used much less screening. Adequate coverage of the female population at risk seems to be of central importance.<\/jats:p>","DOI":"10.1111\/j.1468-0009.2011.00652.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T07:12:03Z","timestamp":1332141123000},"page":"5-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Cervical Cancer Screening in the United States and the Netherlands: A Tale of Two Countries"],"prefix":"10.1111","volume":"90","author":[{"given":"DIK","family":"HABBEMA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"INGE M.C.M.","family":"De KOK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTIN L.","family":"BROWN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"issue":"152","key":"e_1_2_10_2_1","first-page":"210","article-title":"ACOG Committee Opinion: Recommendations on Frequency of Pap Test Screening","volume":"49","author":"ACOG (American Congress of Obstetricians and Gynecologists), Committee on Gynecologic Practice","year":"1995","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"45","key":"e_1_2_10_3_1","first-page":"417","article-title":"ACOG Practice Bulletin: Clinical Management Guidelines for Obstetrician\u2010Gynecologists. 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