{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:51:45Z","timestamp":1790484705237,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T00:00:00Z","timestamp":1140652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We evaluated the long\u2010term safety and efficacy of injectable poly\u2010L\u2010lactic acid (PLLA) for the correction of facial lipoatrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, open\u2010label, comparative, single\u2010centre study of injected PLLA in patients with HIV\u2010related facial lipoatrophy. Thirty subjects were randomized to immediate or delayed PLLA treatments, administered as three sets of bilateral injections, 2 weeks apart, into the deep dermis above the buccal fat pad. Week 24 results have been published previously (Moyle <jats:italic>et al<\/jats:italic>, <jats:italic>HIV Medicine<\/jats:italic> 2004, Vol. 5, pp. 82\u201387). Long\u2010term efficacy was assessed at a recall visit using visual analogue scales (VASs) to record patient satisfaction, and by the Hospital Anxiety and Depression Scale (HADS). Patients also reported any adverse events (AEs) during the treatment period and at the recall visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients returned for the recall visit, a minimum of 18 months post final study treatment. Fourteen of these patients were excluded from the recall visit because of additional treatment with PLLA. Improvements in VAS scores for facial appearance were sustained from baseline to the recall visit in both randomization groups (<jats:italic>P<\/jats:italic>&lt;0.05 and <jats:italic>P<\/jats:italic>&lt;0.001). Trends in improvement in HADS scores were also noted, with patients in the delayed group experiencing significant improvements in depressive symptoms (<jats:italic>P<\/jats:italic>&lt;0.05). One case of injection\u2010site induration and nine cases of injection\u2010site nodules were noted at the recall visit, none of which was described as serious or severe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Physical and psychological benefits of PLLA are sustained over at least 18 months. Delayed AEs include mild nodularity at the treatment site.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2006.00342.x","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T09:17:05Z","timestamp":1140686225000},"page":"181-185","source":"Crossref","is-referenced-by-count":99,"title":["Long\u2010term safety and efficacy of poly\u2010L\u2010lactic acid in the treatment of HIV\u2010related facial lipoatrophy"],"prefix":"10.1111","volume":"7","author":[{"given":"GJ","family":"Moyle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lysakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SE","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,23]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"546","article-title":"Psychosocial impact of the lipodystrophy syndrome in HIV infection","volume":"10","author":"Collins E","year":"2000","journal-title":"AIDS Read"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.79.2.137"},{"key":"e_1_2_6_4_2","first-page":"157","article-title":"Lipodystrophy syndrome in patients with HIV infection","volume":"24","author":"Martinez E","year":"2001","journal-title":"quality of life issues"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200305010-00005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200305010-00004"},{"key":"e_1_2_6_7_2","first-page":"1029","article-title":"Reversibility of lipoatrophy in HIV\u2010infected patients 2 years after switching from a thymidine analogue to abacavir","volume":"18","author":"Martin A","year":"2004","journal-title":"the MITOX Extension Study"},{"key":"e_1_2_6_8_2","first-page":"2471","article-title":"Polylactic acid implants (New\u2010Fill\u00ae) to correct facial lipoatrophy in HIV\u2010infected patients","volume":"17","author":"Valantin MA","year":"2003","journal-title":"results of the open-label study VEGA"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2004.00190.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_6_11_2","first-page":"542","article-title":"Facial enhancement and the European experience with poly\u2010L\u2010lactic acid","volume":"3","author":"Vleggaar D","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_12_2","first-page":"385","article-title":"Poly\u2010L\u2010lactic acid","volume":"3","author":"Woerle B","year":"2004","journal-title":"a temporary filler for soft tissue augmentation"},{"key":"e_1_2_6_13_2","first-page":"1923","article-title":"Lumps and bumps","volume":"112","author":"Douglas RS.","year":"2003","journal-title":"late postsurgical inflammatory and infectious lesions"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.01251.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2004.01.006"},{"key":"e_1_2_6_16_2","unstructured":"Dermik Laboratories.Sculptra\u2122Product Information.http:\/\/www.sculptra.com\/US\/resources\/SculptraPI.pdf2005."},{"key":"e_1_2_6_17_2","first-page":"193","article-title":"Correction of facial deformities with poly\u2010L\u2010lactic acid","volume":"18","author":"Bauer U.","year":"2004","journal-title":"40-month follow-up"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1293.2006.00342.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1293.2006.00342.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:08:09Z","timestamp":1696867689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1293.2006.00342.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,23]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1468-1293.2006.00342.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1293.2006.00342.x","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,23]]}}}