{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:09:11Z","timestamp":1785942551680,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T00:00:00Z","timestamp":1140652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Current research is unclear about the most effective pharmacological agents for managing the loss of weight and fat\u2010free mass common in HIV\/AIDS. The aim of this study was to compare nandrolone decanoate with placebo and testosterone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a multicentre randomized double\u2010blind placebo\u2010controlled trial. Three hundred and three adult HIV\u2010positive male patients with a weight loss of 5\u201315% in the last 12 months, or a body mass index of 17\u201319\u2003kg\/m<jats:sup>2<\/jats:sup>, or a body cell mass\/height ratio lower than 13.5\u2003kg\/m, were randomly assigned to receive nandrolone decanoate (150\u2003mg), testosterone (250\u2003mg) or placebo intramuscularly every 2 weeks for 12 weeks. Fat\u2010free mass, weight, immune markers and perception of treatment were the main outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with nandrolone resulted in significantly greater increases in fat\u2010free mass [mean increase 1.34\u2003kg; 95% confidence interval (CI) 0.60; 2.08\u2003kg] and in weight (mean increase 1.48\u2003kg; 95% CI 0.82; 2.14\u2003kg) compared with placebo. The mean increase in weight with nandrolone of 1.00\u2003kg (95% CI 0.27; 1.74\u2003kg) when compared with testosterone was significant, although the difference in fat free mass did not reach significance (mean increase 0.69\u2003kg; 95% CI\u20130.13; 1.51\u2003kg). Patient perception of benefit was significantly greater in the nandrolone group when compared with both the placebo and the testosterone groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with nandrolone decanoate increased body weight when compared with placebo and testosterone. Nandrolone decanoate treatment resulted in greater increases in fat\u2010free mass than placebo and demonstrated a trend for a significant increase when compared with testosterone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2006.00358.x","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T09:17:05Z","timestamp":1140686225000},"page":"146-155","source":"Crossref","is-referenced-by-count":41,"title":["Effects of nandrolone decanoate compared with placebo or testosterone on HIV\u2010associated 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