{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:41:04Z","timestamp":1697002864255},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T00:00:00Z","timestamp":1143676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of HIV infection or antiretroviral therapy on the intrathoracic fat compartment is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive clinically stable HIV\u2010infected adult patients, irrespective of exposure to antiretroviral therapy, and non\u2010HIV\u2010infected healthy volunteers, both without clinical evidence of body fat changes consistent with lipodystrophy and adjusted for age, gender and body mass index, were recruited for this study. Thoracic and abdominal fat was assessed by computed tomography and compared between patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were nine women (33%) and 18 men (67%) in each group. Nineteen patients (70%) had been taking antiretrovirals for a median of 8 months (interquartile range: 6\u201311). Among the HIV\u2010infected patients, intrathoracic fat (median; interquartile range) did not differ significantly between treated (6.7\u2003cm<jats:sup>2<\/jats:sup>; 4.5\u20138.3\u2003cm<jats:sup>2<\/jats:sup>) and untreated (6.9\u2003cm<jats:sup>2<\/jats:sup>; 5.7\u201310.9\u2003cm<jats:sup>2<\/jats:sup>) individuals (<jats:italic>P<\/jats:italic>=0.288). However, intrathoracic fat content (median; interquartile range) was higher in HIV\u2010infected patients (6.8\u2003cm<jats:sup>2<\/jats:sup>; 5.6\u201310.5\u2003cm<jats:sup>2<\/jats:sup>) than in controls (5.6\u2003cm<jats:sup>2<\/jats:sup>; 3.9\u20136.7\u2003cm<jats:sup>2<\/jats:sup>) (<jats:italic>P<\/jats:italic>=0.025). Intrathoracic fat was positively correlated with intra\u2010abdominal fat both in patients (rho=0.6, <jats:italic>P<\/jats:italic>=0.002) and in controls (rho=0.7, <jats:italic>P<\/jats:italic>=0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In HIV\u2010infected adults without clinical evidence of lipodystrophy, intrathoracic fat content was higher than in healthy persons and positively correlated with intra\u2010abdominal fat content.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2006.00361.x","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T12:16:28Z","timestamp":1143720988000},"page":"213-217","source":"Crossref","is-referenced-by-count":1,"title":["Intrathoracic fat in HIV\u2010infected patients"],"prefix":"10.1111","volume":"7","author":[{"given":"JL","family":"Blanco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Biglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"De Lazzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Milinkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Larrousse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lonca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Laguno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Mallolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JM","family":"Gatell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,30]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"13","article-title":"Metabolic abnormalities and body fat redistribution in HIV\u20101 infected patients","volume":"12","author":"Martinez E","year":"1999","journal-title":"the lipodystrophy syndrome"},{"key":"e_1_2_6_3_2","volume-title":"XIV International AIDS Conference","author":"Grunfeld C","year":"2002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11518-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11443-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/597649"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.22.suppl_1.g02oc08s61"},{"key":"e_1_2_6_8_2","first-page":"663","article-title":"Benign symmetric lipomatosis Launois\u2010Bensaude","volume":"17","author":"Ruzicka T","year":"1987","journal-title":"report of ten cases and review of the literature"},{"key":"e_1_2_6_9_2","first-page":"5163","article-title":"Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome","volume":"88","author":"Iacobellis G","year":"2003","journal-title":"a new indicator of cardiovascular risk"},{"key":"e_1_2_6_10_2","first-page":"592","article-title":"Risk of lipodystrophy in HIV\u20101\u2010infected patients treated with protease inhibitors","volume":"357","author":"Martinez E","year":"2001","journal-title":"a prospective cohort study"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199807000-00003"},{"key":"e_1_2_6_12_2","first-page":"899","article-title":"Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. 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