{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:52:23Z","timestamp":1778914343858,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T00:00:00Z","timestamp":1143676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV\u2010related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In HIV\u2010infected patients, we previously demonstrated a strong relationship between lipodystrophy and levels of adiponectin, an adipose peptide implicated in regulation of glucose and lipid metabolisms. In this study we investigated the effect of HIV on adipocytes, to determine whether HIV can directly infect adipocytes and\/or alter the regulation and secretion of the adipocyte\u2010derived hormone adiponectin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human subcutaneous preadipocytes and adipocytes were exposed to HIV\u20101 under various conditions. Adiponectin was measured in supernatants and cell lysates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although adipocytes expressed CD4, the major HIV receptor, they could not be infected <jats:italic>in vitro<\/jats:italic>. However, exposure to HIV dramatically increased the secretion of adiponectin from human adipocytes, in the absence of infection. This was exacerbated with sustained exposure to HIV in a transwell assay. Further, human peripheral mononuclear cells also produced adiponectin, but this was largely dependent upon T\u2010cell activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We propose that the stimulation of adiponectin production by HIV can perturb adiponectin regulation, leading to substantially decreased levels upon viral suppression by antiretroviral therapy. These data suggest a potential molecular mechanism of adiponectin regulation in HIV\u2010infected patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2006.00372.x","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T12:16:28Z","timestamp":1143720988000},"page":"268-274","source":"Crossref","is-referenced-by-count":15,"title":["Regulation of adiponectin in adipocytes upon exposure to 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