{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:51:13Z","timestamp":1791834673713,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T00:00:00Z","timestamp":1148428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Since the introduction of highly active antiretroviral therapy (HAART) there has been a dramatic reduction in the incidence of Kaposi sarcoma (KS) and an improvement in survival. We wished to examine whether the outcome in pulmonary KS (pKS) has also altered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a single\u2010institution cohort of 1140 HIV\u2010positive patients with KS, 305 patients were diagnosed in the HAART era (1996\u20132004). We examined the clinicopathological features and outcomes of these patients, of whom 25 had pKS and 280 did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with pKS had lower CD4 cell counts at the time of KS diagnosis (Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test <jats:italic>P<\/jats:italic>=0.005). The incidence of pKS was higher in African patients than in non\u2010African patients in this sample (Fisher's test, <jats:italic>P<\/jats:italic>=0.001). There were no significant differences in age, gender, plasma HIV\u20101 viral load or prior HAART treatment at the time of KS diagnosis. Five\u2010year overall survival in the pKS group was 49% [95% confidence interval (CI) 26\u201373%] as compared with 82% (95% CI 76\u201387%) for the non\u2010pKS group (log rank, <jats:italic>P<\/jats:italic>&lt;0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PKS remains an ominous diagnosis in the era of HAART, with a median survival of just 1.6 years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2006.00378.x","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T08:22:49Z","timestamp":1148458969000},"page":"291-293","source":"Crossref","is-referenced-by-count":41,"title":["Pulmonary Kaposi sarcoma in the era of highly active antiretroviral therapy"],"prefix":"10.1111","volume":"7","author":[{"given":"C","family":"Palmieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Thirlwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Newsom\u2010Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010M","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BG","family":"Gazzard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199714000-00010"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/27.6.1078"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.22.1823"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-199905010-00078"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199807000-00002"},{"issue":"1","key":"e_1_2_5_7_2","first-page":"34","article-title":"Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non\u2010Hodgkin's lymphomas among HIV\u20101\u2010infected individuals. 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