{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:07:29Z","timestamp":1761487649384},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,24]],"date-time":"2006-07-24T00:00:00Z","timestamp":1153699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess long\u2010term changes in lipids and lipoproteins concentrations associated with exposure to non\u2010nucleoside reverse transcriptase inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Long\u2010term analysis of plasma lipid concentrations was performed in patients starting first\u2010line antiretroviral therapy with stavudine (d4T) and lamivudine, and either nevirapine or efavirenz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Concentrations of total cholesterol, low\u2010density lipoprotein cholesterol and triglycerides continued to increase, while high\u2010density lipoprotein cholesterol showed a slight decrease compared with earlier reported increases after 48 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Changes in body fat distribution expected to occur with continued exposure to d4T could offer a potential explanation for these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2006.00390.x","type":"journal-article","created":{"date-parts":[[2006,7,24]],"date-time":"2006-07-24T22:17:54Z","timestamp":1153779474000},"page":"347-350","source":"Crossref","is-referenced-by-count":11,"title":["Plasma lipid concentrations after 1.5 years of exposure to nevirapine or efavirenz together with stavudine and lamivudine"],"prefix":"10.1111","volume":"7","author":[{"given":"F","family":"Van Leth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DB","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JMA","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199907090-00001"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.7.700"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200112070-00008"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1310\/F2V7-3R46-VX6J-241R"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030218"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010019"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/jama.1988.03410050061031","article-title":"Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study","volume":"260","author":"Manninen V","year":"1988","journal-title":"J Am Med Assoc"},{"key":"e_1_2_5_9_2","first-page":"191","article-title":"Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral\u2010naive patients","volume":"292","author":"Gallant JE","year":"2004","journal-title":"a 3-year randomized trial"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2343"},{"key":"e_1_2_5_11_2","first-page":"1029","article-title":"Reversibility of lipoatrophy in HIV\u2010infected patients 2 years after switching from a thymidine analogue to abacavir","volume":"18","author":"Martin A","year":"2004","journal-title":"the MITOX Extension Study"},{"key":"e_1_2_5_12_2","first-page":"263","article-title":"Improvement in lipoatrophy associated with highly active antiretroviral therapy in human immunodeficiency virus\u2010infected patients switched from stavudine to abacavir or zidovudine","volume":"38","author":"McComsey GA","year":"2004","journal-title":"the results of the TARHEEL study"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1293.2006.00390.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1293.2006.00390.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T18:11:16Z","timestamp":1696961476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1293.2006.00390.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,24]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1468-1293.2006.00390.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1293.2006.00390.x","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,24]]}}}