{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:43:10Z","timestamp":1697006590831},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate the accuracy of three\u2010dimensional laser scanning as an objective method for detecting facial changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Facial laser scanning was performed at baseline and repeated after a median of 10 months in 24 HIV\u2010infected patients, 12 with ongoing lipodystrophy, five with &gt;10% weight loss and seven with &gt;10% weight gain. Surface volume change was estimated using a standardized technique, and compared with change in cheek fat measured by magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median laser scanning surface volume changes were \u22122.1 (range \u22124.6 to \u22120.8)\u2003mL in the lipoatrophy group, \u22121.5 (range \u22126.8 to \u22121.3)\u2003mL in the weight loss group and +3.1 (range \u22120.2 to +5.4)\u2003mL in the weight gain group (the median MRI cheek fat changes were \u22124.6, \u22123.7 and +7.0\u2003mL in the three groups, respectively). Laser scanning and MRI measurements were not significantly associated in lipoatrophy patients (<jats:italic>r<\/jats:italic>=0.34, <jats:italic>P<\/jats:italic>=0.28), but there was a good association in patients who changed weight (<jats:italic>r<\/jats:italic>=0.71, <jats:italic>P<\/jats:italic>=0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laser scanning detects changes in the appropriate direction, although it underestimates MRI\u2010measured cheek fat changes. Laser scanning may be useful as an objective measure of cheek surface volume changes, but needs further validation in larger clinical cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2007.00501.x","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T12:02:30Z","timestamp":1192708950000},"page":"498-503","source":"Crossref","is-referenced-by-count":4,"title":["Validation of three\u2010dimensional laser scanning for the assessment of facial fat changes"],"prefix":"10.1111","volume":"8","author":[{"given":"NI","family":"Paton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u2010Y","family":"Sitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naing","family":"Oo 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