{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:16:53Z","timestamp":1758709013948},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>GB virus type C (GBV\u2010C) viraemia is associated with a beneficial outcome in HIV\u2010infected individuals in several though not all studies. GBV\u2010C viraemia was examined in a matched case\u2013control study of 133 HIV\u2010infected pregnant women who transmitted HIV to their infants (\u2018cases\u2019) and 266 non\u2010transmitting controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HIV\u2010infected children and controls were pair\u2010matched for high\u2010risk delivery, race and year of delivery. GBV\u2010C status was determined in maternal plasma samples obtained at or within 3 months of delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pregnant women with GBV\u2010C viraemia (11% of those studied) had lower HIV RNA levels (<jats:italic>P<\/jats:italic>=0.01) and higher CD4 percentages (<jats:italic>P<\/jats:italic>=0.006) than women without GBV\u2010C. A trend towards decreased mother\u2010to\u2010child transmission in the multivariate analysis was observed among GBV\u2010C viraemic women delivering after highly active antiretroviral therapy (HAART) became available [odds ratio (OR) 0.30, 95% confidence interval (CI) 0.08\u20131.05; <jats:italic>P<\/jats:italic>=0.06], but not in women delivering prior to the widespread use of HAART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GBV\u2010C viraemia was associated with a beneficial effect on CD4 percentage and HIV RNA level in these pregnant women, and was also associated with a trend towards reduced risk of mother\u2010to\u2010child HIV transmission among women after HAART became available. Further studies with larger or multiple cohorts are necessary to assess possible benefits in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2007.00510.x","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T08:02:30Z","timestamp":1192694550000},"page":"561-567","source":"Crossref","is-referenced-by-count":9,"title":["Impact of GB virus type C infection on mother\u2010to\u2010child HIV transmission in the Women and Infants Transmission Study Cohort"],"prefix":"10.1111","volume":"8","author":[{"given":"E","family":"Handelsman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hershow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LM","family":"Mofenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FB","family":"Hollinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KT","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SK","family":"Burchett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Klinzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JT","family":"Stapleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Women and Infants Transmission Study Group (WITS)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37697335149.x"},{"key":"e_1_2_6_3_2","first-page":"1255","article-title":"GB virus type C\/hepatitis G virus","volume":"5","author":"Polgreen PM","year":"2003","journal-title":"a nonpathogenic flavivirus associated with prolonged survival in HIV-infected individuals"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39943"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260234"},{"key":"e_1_2_6_6_2","unstructured":"KlinzmanD KatzL GeorgeSLet al.GB virus C\/hepatitis G virus:does clearance of viremia differ based on mode of transmission? 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