{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T02:04:49Z","timestamp":1725501889088},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>HIV infection and its treatment, specifically protease inhibitor (PI) therapy, have been associated with an increased risk for cardiovascular disease. Heart rate recovery (HRR) following peak exercise is predictive of future cardiovascular events and mortality in the general population. Nothing is known regarding HRR in individuals infected with HIV on highly active antiretroviral therapy (HAART).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>HIV\u2010positive subjects on HAART that included a PI (HIV+PI, <jats:italic>n<\/jats:italic>=19), HIV\u2010positive subjects on HAART that did not include a PI (HIV+noPI, <jats:italic>n<\/jats:italic>=19) and HIV\u2010seronegative age, gender and body mass index (BMI) matched controls (Cntl, <jats:italic>n<\/jats:italic>=15) underwent a graded maximal exercise test on a cycle ergometer to volitional exhaustion. A continuous electrocardiogram was recorded and HRR was monitored every 30\u2003s for 2\u2003min post exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HRR at 1.5 and 2\u2003min was significantly delayed in HIV\u2010positive subjects both on and not on PI\u2010based HAART compared with controls (<jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HRR is impaired in HIV\u2010positive individuals on HAART, whether or not the HAART includes a PI, compared with age, gender, BMI, and activity level matched HIV\u2010seronegative controls. Abnormal HRR may reflect cardio\u2010autonomic dysfunction and may be an independent risk factor for future cardiac events in HIV\u2010positive individuals that receive HAART.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2007.00524.x","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T21:37:26Z","timestamp":1201901846000},"page":"96-100","source":"Crossref","is-referenced-by-count":15,"title":["Post\u2010exercise heart rate recovery in HIV\u2010positive individuals on highly active antiretroviral therapy. 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