{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:53:11Z","timestamp":1779144791700,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,23]],"date-time":"2008-01-23T00:00:00Z","timestamp":1201046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to determine the incidence of myocardial dysfunction in an HIV\u2010infected population receiving state\u2010of\u2010the\u2010art treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between April 2001 and July 2002, 91 HIV\u2010infected patients had a radionuclide ventriculography performed with determination of right ventricular ejection fraction (RVEF) and left ventricular ejection fraction (LVEF), as well as measurement of brain natriuretic peptide (BNP). Between July 2005 and January 2007, 63 patients (69%) agreed to participate in a follow\u2010up study with a mean follow\u2010up of 4.5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had normal LVEF at both examinations. A minimal increase in mean LVEF of 0.02 was observed at follow\u2010up (<jats:italic>P<\/jats:italic>=0.01). At the initial visit, four patients [6%; 95% confidence interval (CI) 2\u201315%] had a reduced RVEF, and at follow\u2010up two patients (3%; 95% CI 0\u201311%) had slightly reduced RVEF. No significant change in mean RVEF was found. No patients had increased BNP and no change in mean plasma BNP was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIV\u2010related cardiomyopathy appears not to constitute a problem in closely monitored, well\u2010treated HIV\u2010infected patients. Compared with pre\u2010highly active antiretroviral therapy (HAART) studies, it seems that the improvement in immunocompetency and viral load has removed the problem of HIV\u2010related cardiomyopathy. Although HAART has been suggested as a possible new cause of cardiomyopathy, we did not find any evidence of this.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2007.00531.x","type":"journal-article","created":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T02:14:56Z","timestamp":1203300896000},"page":"180-186","source":"Crossref","is-referenced-by-count":21,"title":["Right and left cardiac function in HIV\u2010infected patients investigated using radionuclide ventriculography and brain natriuretic peptide: a 5\u2010year follow\u2010up 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