{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:03:48Z","timestamp":1787897028539,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T00:00:00Z","timestamp":1201737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>A working group of the European AIDS Clinical Society (EACS) have developed these guidelines for European clinicians to help them in the treatment of adults with HIV infection. This third version of the guidelines includes, as new topics, the assessment of patients at initial and subsequent clinic visits as well as post\u2010exposure prophylaxis. A revision of the 2005 guidelines based on current data includes changes in the sections on primary HIV infection, when to initiate therapy, which drug combinations are preferred as initial combination regimens for antiretroviral\u2010na\u00efve patients, how to manage virological failure and the treatment of HIV during pregnancy.<\/jats:p><jats:p>In Europe, there is a wide range of clinical practices in antiretroviral therapy depending on various factors such as drug registration, national policies, local availability, reimbursement and access to treatment. These can vary greatly from one country to another, especially in Central and Eastern parts of Europe.<\/jats:p><jats:p>These guidelines are intended to help clinicians achieve the best care for their patients. In some countries, particularly where the quality of and access to care are not optimal, these guidelines should help AIDS societies and physicians or patient group organizations to negotiate with their national health authorities with a view to implementing what should be the standard of care for HIV\u2010infected patients all over Europe.<\/jats:p>","DOI":"10.1111\/j.1468-1293.2007.00533.x","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T21:37:26Z","timestamp":1201901846000},"page":"65-71","source":"Crossref","is-referenced-by-count":192,"title":["European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of HIV\u2010infected adults"],"prefix":"10.1111","volume":"9","author":[{"given":"N","family":"Clumeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pozniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Raffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EACS Executive Committee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,31]]},"reference":[{"key":"e_1_2_4_2_2","unstructured":"SterneJ MayM CostagliolaDet al. Estimating the optimum CD4 threshold for starting HAART antiretroviral\u2010na\u00efve HIV\u2010infected individuals. 13th Conference on Retroviruses and Opportunistic Infections; February 5\u20138 2006; Denver Colorado [Abstract 525]."},{"key":"e_1_2_4_3_2","unstructured":"MarinB Thi\u00e9bautR RondeauVet al. Association between CD4 and HIV RNA with non AIDS\u2010related causes of death in the era of combination antiretroviral therapy (cART). Third International AIDS Society Conference of HIV Pathogenesis Treatment and Prevention; July 22\u201325 2007; Sydney Australia [Abstract WEPEB019]."},{"key":"e_1_2_4_4_2","first-page":"119","article-title":"Prognosis of HIV1\u2010infected patients starting highly active antiretroviral therapy","volume":"360","author":"Egger M","year":"2002","journal-title":"a collaborative analysis of prospective studies"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200401020-00006"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051871"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16589-6"},{"key":"e_1_2_4_8_2","unstructured":"US Department of Health and Human Services.Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV\u2010infected women for maternal health and interventions to reduce perinatal HIV\u20101 transmission. Use of antiretroviral agents in HIV\u2010infected adults in the United States. Rockville MD: HIV\/AIDS Treatment Information Service. Availablehttp:\/\/AIDSinfo.nih.gov"},{"key":"e_1_2_4_9_2","unstructured":"HarrisonLH Do LagoRF MoreiraRI MendelsohnAB SchechterMl.Post\u2010sexual\u2010exposure chemoprophylaxis (PEP) for HIV: a prospective cohort study of behavioral impact.8th Conference on Retroviruses and Opportunistic Infections Chicago Illinois February 4\u20138 2001 [Abstract 225]."},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200404150-00010"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/426589"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1293.2007.00533.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1293.2007.00533.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:50:20Z","timestamp":1696877420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1293.2007.00533.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,31]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1468-1293.2007.00533.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1293.2007.00533.x","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,31]]}}}