{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:26:47Z","timestamp":1787819207109,"version":"build-2784847793"},"reference-count":103,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T00:00:00Z","timestamp":1270598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>HIV\u2010related pulmonary arterial hypertension (PAH) is a rare entity but is associated with significant morbidity and mortality. The literature describing the outcomes of therapy for this disease is limited to case series and cohort studies. The objective of this study was to systematically review and synthesize the literature on HIV\u2010related PAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE, PapersFirst, the Cochrane collaboration and the Cochrane Register of controlled trials were searched with pre\u2010defined search terms. Randomized controlled trials, observational cohort studies, case\u2013control studies and case reports were considered for inclusion in the qualitative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 180 case reports of PAH in HIV\u2010infected patients were identified. Twenty\u2010six were excluded and thus 154 case reports were included in the qualitative analysis. Thirteen cohort, one case series and two case\u2013control studies were also identified and included in the review. The average baseline CD4 count at the time of diagnosis of PAH was 352 \u00b1 304\u2003cells\/\u03bcL. The average time from diagnosis of HIV infection to diagnosis of PAH was 4.3 \u00b1 4.0 years. Predominant chest X\u2010ray findings included cardiomegaly (80%) and pulmonary arterial enlargement (75%). Highly active antiretroviral therapy, bosentan, and prostaglandin therapy have all been reported to be beneficial in improving haemodynamic and functional status in HIV\u2010related PAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HIV\u2010related PAH is a rare entity with clinical, laboratory, imaging and pathological manifestations similar to those of idiopathic PAH. The evidence for various treatments is limited to cohort, case series and case\u2013control studies. Randomized controlled trials are needed to properly assess the utility of these therapies in the treatment of HIV\u2010related PAH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2010.00829.x","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T01:24:47Z","timestamp":1270689887000},"page":"620-634","source":"Crossref","is-referenced-by-count":42,"title":["HIV and pulmonary arterial hypertension: a systematic review"],"prefix":"10.1111","volume":"11","author":[{"given":"S","family":"Janda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BS","family":"Quon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Swiston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,7]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"293","article-title":"HIV\u2010associated vascular diseases","volume":"133","author":"Monsuez JJ","year":"2009","journal-title":"structural and functional changes, clinical implications"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.024"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00094808"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.3.9117037"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2722"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-541OC"},{"key":"e_1_2_6_8_2","first-page":"1133","article-title":"HIV\u2010related pulmonary hypertension","volume":"118","author":"Mehta NJ","year":"2000","journal-title":"analytic review of 131 cases"},{"key":"e_1_2_6_9_2","first-page":"31","article-title":"Primary pulmonary hypertension in HIV patients","volume":"52","author":"Pellicelli AM","year":"2001","journal-title":"a systematic review"},{"key":"e_1_2_6_10_2","first-page":"2008","article-title":"Meta\u2010analysis of observational studies in epidemiology","volume":"283","author":"Stroup DF","year":"2000","journal-title":"a proposal for reporting. 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