{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:58:49Z","timestamp":1790852329603,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2012,5]]},"abstract":"Objectives<\/jats:title>Treated HIV<\/jats:styled-content>\u20101\u2010infected patients with lipodystrophy often develop insulin resistance and proatherogenic dyslipidaemia. Zinc alpha\u20102 glycoprotein (ZAG<\/jats:styled-content>) is a recently characterized adipokine which has been shown to be involved in the development of obesity and metabolic syndrome in uninfected subjects. We assessed the relationship between circulating ZAG<\/jats:styled-content> levels and metabolic derangements in HIV<\/jats:styled-content>\u20101\u2010infected patients receiving antiretroviral drugs.<\/jats:p><\/jats:sec>Methods<\/jats:title>Plasma ZAG<\/jats:styled-content> levels were assessed in 222 individuals: 166 HIV<\/jats:styled-content>\u20101\u2010infected patients treated with antiretroviral drugs (77 with lipodystrophy and 89 without lipodystrophy) and 56 uninfected controls. Plasma ZAG<\/jats:styled-content> levels were assessed by enzyme\u2010linked immunosorbent assay (ELISA<\/jats:styled-content>) and were correlated with fat distribution abnormalities and metabolic parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>HIV<\/jats:styled-content>\u20101\u2010infected patients had lower plasma ZAG<\/jats:styled-content> levels compared with uninfected controls (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001). No differences were found in ZAG<\/jats:styled-content> plasma levels according to the presence of lipodystrophy, components of the metabolic syndrome or type of antiretroviral treatment regimen. Circulating ZAG<\/jats:styled-content> levels were strongly determined by high\u2010density lipoprotein cholesterol (HDLc<\/jats:styled-content>) in men (B<\/jats:styled-content><\/jats:italic>\u2009=\u20090.644; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001) and showed a positive correlation with total cholesterol (r<\/jats:styled-content><\/jats:italic>\u2009=\u20090.312; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001) and HDLc<\/jats:styled-content> (r<\/jats:italic>\u2009=\u20090.216; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.005).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HIV<\/jats:styled-content>\u20101\u2010infected patients have lower plasma ZAG<\/jats:styled-content> levels than uninfected controls. In infected patients, plasma ZAG<\/jats:styled-content> levels are in close relationship with total cholesterol and HDLc<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2011.00976.x","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T08:58:18Z","timestamp":1326963498000},"page":"297-303","source":"Crossref","is-referenced-by-count":21,"title":["Zinc alpha\u20102 glycoprotein is implicated in dyslipidaemia in HIV<\/scp>\u20101\u2010infected patients treated with antiretroviral drugs"],"prefix":"10.1111","volume":"13","author":[{"given":"V","family":"Ceperuelo\u2010Mallafr\u00e9","sequence":"first","affiliation":[{"name":"Joan XXIII University Hospital, IISPV University Rovira i Virgili Tarragona Spain"},{"name":"CIBER Pathophysiology of Obesity and Nutrition (CIBERobn) Virgen de la Victoria Clinic Hospital M\u00e1laga 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