{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:13:27Z","timestamp":1719926007963},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Objectives<\/jats:title>The aim of the study was to evaluate fat tissue distribution in HIV<\/jats:styled-content>\u2010infected patients with suppressed viraemia treated with darunavir\/ritonavir (darunavir\/r) monotherapy versus darunavir\/r triple therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study was a substudy of the randomized, multicentre, open\u2010label MONOI\u2010ANRS<\/jats:styled-content> 136 trial. Body fat distribution and metabolic parameters were measured at baseline, week 48 and week 96.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 156 patients of the 225 initially enrolled in the MONOI<\/jats:styled-content> trial participated in this study, 75 in the darunavir\/r monotherapy arm and 81 in the darunavir\/r triple\u2010therapy arm. The median limb fat increase from baseline was +0.34\u2009kg [interquartile range (IQR<\/jats:styled-content>) \u20130.040 to +1.140\u2009kg; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001] at week 48 and +0.33\u2009kg (IQR<\/jats:styled-content> \u20130.14 to +1.26\u2009kg; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001) at week 96 in the monotherapy arm, while there was no change (\u20130.02\u2009kg; IQR<\/jats:styled-content> \u20130.53 to +0.52\u2009kg) at week 48 and then an increase of +0.23\u2009kg (IQR<\/jats:styled-content> \u20130.45 to +0.87\u2009kg; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.046) at week 96 in the triple\u2010therapy arm. The two arms differed significantly at week 48 (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001) but not at week 96. The median increase in trunk fat was +0.73\u2009kg (IQR<\/jats:styled-content> \u20130.24 to +1.60\u2009kg; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001) and 0.60\u2009kg (IQR<\/jats:styled-content> \u20130.41 to +1.49\u2009kg; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.03) at week 48 and +1.16\u2009kg (IQR<\/jats:styled-content> \u20130.17 to +2.75\u2009kg; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001) and +0.90\u2009kg (IQR<\/jats:styled-content> \u20130.51 to +2.34\u2009kg; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001) at week 96 in the monotherapy and triple\u2010therapy arms, respectively, with no difference between arms. At week 96, the only biological change was a glucose level elevation in the monotherapy arm (median +4.0\u2009mg\/dL; IQR<\/jats:styled-content> \u20134.0 to +7.0\u2009mg\/dL) compared with the triple\u2010therapy arm (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.012).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Overall, body fat tissue increased in patients on darunavir\/r monotherapy and triple therapy, with no difference between the arms over 96 weeks. The only difference found was a delayed increase in limb fat tissue in the triple\u2010therapy arm compared with the monotherapy arm in the first year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2012.01004.x","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T03:15:35Z","timestamp":1331781335000},"page":"505-515","source":"Crossref","is-referenced-by-count":12,"title":["Body fat distribution in HIV<\/scp>\u2010infected patients treated for 96 weeks with darunavir\/ritonavir monotherapy versus darunavir\/ritonavir plus nucleoside reverse transcriptase inhibitors: the MONOI\u2010ANRS<\/scp>136 Substudy"],"prefix":"10.1111","volume":"13","author":[{"given":"MA","family":"Valantin","sequence":"first","affiliation":[{"name":"INSERM UMR\u2010S 943 and University Pierre and Marie Curie (UPMC) Paris France"},{"name":"Department of Infectious Diseases Assistance Publique H\u00f4pitaux de Paris (AP\u2010HP) Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kolta","sequence":"additional","affiliation":[{"name":"Rheumatology Department Paris\u2010Descartes University, AP\u2010HP, Cochin Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Flandre","sequence":"additional","affiliation":[{"name":"INSERM UMR\u2010S 943 and University Pierre and Marie Curie (UPMC) Paris France"},{"name":"Department of Virology, AP\u2010HP Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Algarte Genin","sequence":"additional","affiliation":[{"name":"INSERM UMR\u2010S 943 and University Pierre and Marie Curie (UPMC) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JL","family":"Meynard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, AP\u2010HP Saint Antoine Hospital 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