{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:04:48Z","timestamp":1773745488698,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T00:00:00Z","timestamp":1332288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lluita Contra La SIDA Foundation"},{"name":"Red de Investigaci\u00f3n en SIDA (RIS)"},{"name":"ART AIDS Foundation"},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Obra Social Caixa Sabadell"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2012,10]]},"abstract":"Background<\/jats:title>Genital infections with low\u2010risk (LR<\/jats:styled-content>) and high\u2010risk (HR<\/jats:styled-content>) human papillomavirus (HPV<\/jats:styled-content>) genotypes are associated with ano\u2010genital condylomata and anal squamous cell cancer. HPV<\/jats:styled-content>\u2010related pathologies in HIV<\/jats:styled-content>\u2010infected men are a serious concern. In this study, the prevalence of anal condylomata and their association with cytological abnormalities and HPV<\/jats:styled-content> infection in the anal canal in HIV<\/jats:styled-content>\u2010infected men [men who have sex with men (MSM<\/jats:styled-content>) and heterosexuals] were estimated.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a cross\u2010sectional study based on the first visits of patients in the C<\/jats:styled-content>an R<\/jats:styled-content>uti HIV<\/jats:styled-content>\u2010positive M<\/jats:styled-content>en (CARH<\/jats:styled-content>\u00b7MEN<\/jats:styled-content>) cohort. Anal condylomata were assessed by clinical and proctological examination. Samples from the anal canal were collected for HPV<\/jats:styled-content> genotyping and cytological diagnoses.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 640 HIV<\/jats:styled-content>\u2010infected men (473 MSM<\/jats:styled-content> and 167 heterosexuals) were included in the study. The overall prevalence of anal condylomata was 25% [157 of 640; 95% confidence interval (CI<\/jats:styled-content>) 21\u201328%]; in MSM<\/jats:styled-content> it was 28% and in heterosexuals it was 15% [odds ratio (OR<\/jats:styled-content>) 2.2; 95% CI<\/jats:styled-content> 1.4\u20133.5]. In patients with anal condylomata, HPV<\/jats:styled-content> infection in the anal canal was more prevalent (92% vs.<\/jats:italic> 67% in those without anal condylomata; OR<\/jats:styled-content> 8.5; 95% CI<\/jats:styled-content> 3.2\u201322). This higher HPV<\/jats:styled-content> prevalence involved at least two HPV<\/jats:styled-content> genotypes (OR<\/jats:styled-content> 4.0; 95% CI<\/jats:styled-content> 2.2\u20137.1), mainly HR<\/jats:styled-content> genotypes (OR<\/jats:styled-content> 3.3; 95% CI<\/jats:styled-content> 1.7\u20136.4). Similarly, the cumulative prevalence of HPV<\/jats:styled-content>\u20106 and HPV<\/jats:styled-content>\u201011 was higher in patients with anal condylomata (63% vs.<\/jats:italic> 19% in those without anal condylomata). Having anal condylomata was associated with higher prevalences of cytological abnormalities (83% vs.<\/jats:italic> 32% in those without anal condylomata; OR<\/jats:styled-content> 6.9; 95% CI<\/jats:styled-content> 3.8\u201312.7) and high\u2010grade squamous intraepithelial lesions (HSILs<\/jats:styled-content>) (9% vs.<\/jats:italic> 3% in those without anal condylomata; OR<\/jats:styled-content> 9.0; 95% CI<\/jats:styled-content> 2.9\u201328.4) in the anal canal.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HIV<\/jats:styled-content>\u2010infected men with anal condylomata were at risk of presenting HSILs<\/jats:styled-content> and harbouring multiple HR HPV<\/jats:styled-content> infections in the anal canal. Although MSM<\/jats:styled-content> presented the highest prevalence of anal condylomata, heterosexual men also had a clinically important prevalence. Our findings emphasize the importance of screening and follow\u2010up for condylomata in the anal canal in HIV<\/jats:styled-content>\u2010infected men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2012.01013.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T10:29:09Z","timestamp":1444732149000},"page":"549-557","source":"Crossref","is-referenced-by-count":31,"title":["Condylomata, cytological abnormalities and human papillomavirus infection in the anal canal in HIV<\/scp>\u2010infected men"],"prefix":"10.1111","volume":"13","author":[{"given":"L","family":"Darwich","sequence":"first","affiliation":[{"name":"Retrovirology Laboratory IrsiCaixa Foundation Barcelona Spain"},{"name":"Department of Sanitat i Anatomia Animal Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MP","family":"Ca\u00f1adas","sequence":"additional","affiliation":[{"name":"Retrovirology Laboratory IrsiCaixa Foundation Barcelona Spain"},{"name":"Labco.GeneralLab Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Videla","sequence":"additional","affiliation":[{"name":"Lluita Contra La SIDA Foundation Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Coll","sequence":"additional","affiliation":[{"name":"Retrovirology Laboratory IrsiCaixa Foundation Barcelona Spain"},{"name":"Lluita Contra La SIDA Foundation Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pi\u00f1ol","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital Germans Trias i Pujol, UAB Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Cobarsi","sequence":"additional","affiliation":[{"name":"Lluita Contra La SIDA Foundation Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RA","family":"Molina\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Sanitat i Anatomia Animal Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Vela","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital Germans Trias i Pujol, UAB Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Garc\u00eda\u2010Cuy\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital Germans Trias i Pujol, UAB Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Llatjos","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital Germans Trias i Pujol, UAB Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Sirera","sequence":"additional","affiliation":[{"name":"Lluita Contra La SIDA Foundation Badalona Spain"},{"name":"HIV Clinical Unit Department of Medicine University Hospital Germans Trias i Pujol, UAB Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Clotet","sequence":"additional","affiliation":[{"name":"Retrovirology Laboratory IrsiCaixa Foundation Barcelona Spain"},{"name":"Lluita Contra La SIDA Foundation Badalona Spain"},{"name":"HIV Clinical Unit Department of Medicine University Hospital Germans Trias i Pujol, UAB Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the HIV\u2010HPV Can Ruti 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