{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:51:30Z","timestamp":1758127890170},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T00:00:00Z","timestamp":1333065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to evaluate the interleukin\u201017 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017) plasma level in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101\u2010infected patients and its relation to central obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010four <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101\u2010infected patients [42 with visceral obesity (group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) and 42 without visceral obesity (group <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>)] and 46 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative subjects [23 with visceral obesity (group <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) and 23 without visceral obesity (group <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>)] were enrolled in the study. Sonographic measurements of perirenal fat diameter\/body mass index (<jats:styled-content style=\"fixed-case\">PRFD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) were used to assess visceral adipose tissue thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101\u2010infected patients had higher plasma levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 than <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative subjects [837.8\u2009\u00b1\u2009260\u2009<jats:styled-content style=\"fixed-case\">pg\/mL<\/jats:styled-content> (mean \u00b1 standard deviation) <jats:italic>vs<\/jats:italic>. 395.3\u2009\u00b1\u2009138.6\u2009<jats:styled-content style=\"fixed-case\">pg\/mL<\/jats:styled-content>, respectively; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001]. Furthermore, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u20101\u2010infected patients with a diagnosis of visceral obesity had lower levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 than <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected lean patients (756.9\u2009\u00b1\u2009282.9\u2009<jats:styled-content style=\"fixed-case\">pg\/mL<\/jats:styled-content> <jats:italic>vs<\/jats:italic>. 918.7\u2009\u00b1\u2009208.4\u2009<jats:styled-content style=\"fixed-case\">pg\/mL<\/jats:styled-content>, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.21; <jats:italic>P<\/jats:italic>\u2009=\u20090.03) and waist circumference (<jats:italic>r<\/jats:italic>\u2009=\u20090.48; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were significantly associated with visceral adipose tissue thickness. A negative correlation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.23; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with <jats:styled-content style=\"fixed-case\">PRFD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests a linear negative association between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and visceral adipose tissue thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-1293.2012.01014.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T12:17:01Z","timestamp":1333455421000},"page":"574-577","source":"Crossref","is-referenced-by-count":7,"title":["Interleukin\u201017 regulates visceral obesity in HIV\u20101\u2010infected patients"],"prefix":"10.1111","volume":"13","author":[{"given":"A","family":"Zizza","sequence":"first","affiliation":[{"name":"Institute of Clinical Physiology National Research Council  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Guido","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene Department of Biological and Environmental Sciences and Technologies University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Grima","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases HIV Center S. 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