{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:56:07Z","timestamp":1789257367399,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T00:00:00Z","timestamp":1085529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Despite the continuous description of new conditions pre\u2010disposing for cerebral venous thrombosis (CVT), no apparent cause is found in about 30% of cases. Hyperhomocysteinemia (hyper\u2010Hcy) is an established risk factor for deep venous thrombosis and stroke but has not been clearly associated with increased risk of CVT. We assessed the prevalence of hyper\u2010Hcy and other thrombophilic risk factors in a population of 26 consecutive patients with non\u2010pyogenic CVT, by review of a prospectively maintained database. The prevalences of hyper\u2010Hcy and prothrombin G20210A, factor V G1691A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations in these patients were compared with those in 100 healthy controls and 100 patients with cerebroarterial disease. The prevalence of hyper\u2010Hcy was greater in patients with CVT (10\/26, 38.5%) than healthy controls (13\/100; OR 4.18, 95% CI 1.58\u201311.16) and comparable with that in patients with cerebroarterial disease (42\/100). No significant differences were found in the prevalences of prothrombin or MTHFR mutation. No factor V mutation was found. Our findings indicate that hyper\u2010Hcy is associated with an increased risk of CVT. Additional prospective cohort studies on large series of patients are required to clarify the time relationship between hyper\u2010Hcy and the thrombotic event.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2004.00802.x","type":"journal-article","created":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T16:06:41Z","timestamp":1085587601000},"page":"405-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hyperhomocysteinemia and other thrombophilic risk factors in 26 patients with cerebral venous thrombosis"],"prefix":"10.1111","volume":"11","author":[{"given":"G.","family":"Boncoraglio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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