{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:26:41Z","timestamp":1790857601275,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T00:00:00Z","timestamp":1111017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>Multiple sclerosis (MS) with clinical onset after 50\u2003years of age is unusual (between 1 and 6%) and is frequently misdiagnosed. Furthermore, brain magnetic resonance imaging (MRI) abnormalities are frequently observed in subjects over 50\u2003years of age. The aim of this study was to describe brain MRI in late\u2010onset MS to evaluate the sensitivity and specificity of radiological MS criteria in patients aged over 50\u2003years. We evaluated the brain MRI of 20 patients with onset of MS after 50\u2003years of age. We compared these MRI with 26 controls matched for age, sex and vascular risk factors. MRI were blindly analysed by two neuroradiologists according to Paty <jats:italic>et al.<\/jats:italic>'s [<jats:italic>Neurology<\/jats:italic><jats:bold>38<\/jats:bold> (1988) 180] criteria, Fazekas <jats:italic>et al.<\/jats:italic>'s [<jats:italic>Neurology<\/jats:italic><jats:bold>38<\/jats:bold> (1988) 1822] criteria and Barkhof <jats:italic>et al.<\/jats:italic>'s [<jats:italic>Brain<\/jats:italic><jats:bold>120<\/jats:bold> (1997) 2059] criteria. The mean age at MRI scanning was 58\u2003years. Sensitivity was 90% for Paty <jats:italic>et al.<\/jats:italic>'s criteria, 80% for Fazekas <jats:italic>et al.<\/jats:italic>'s criteria and 85% for Barkhof <jats:italic>et al.<\/jats:italic>'s criteria. Specificity was 54% for Paty <jats:italic>et al.<\/jats:italic>'s criteria, 69% for Fazekas <jats:italic>et al.<\/jats:italic>'s criteria and 65% for Barkhof <jats:italic>et al.<\/jats:italic>'s criteria. Barkhof <jats:italic>et al.<\/jats:italic>'s criteria are less specific in older patients than in young patients. We suggest that spinal cord MRI and cerebrospinal fluid analysis should be systematically performed in suspected late\u2010onset MS in order to increase the specificity of the diagnosis.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2004.01103.x","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T21:42:16Z","timestamp":1111095736000},"page":"241-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Brain MRI in late\u2010onset multiple sclerosis"],"prefix":"10.1111","volume":"12","author":[{"given":"J.","family":"de Seze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Delalande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Michelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Y.","family":"Gauvrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Mackowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ferriby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Stojkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Defebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Pruvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vermersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.11.2059"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.2.226"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10240"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.9"},{"key":"e_1_2_11_6_1","first-page":"1082","article-title":"Late onset MS","volume":"158","author":"Delalande S","year":"2002","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.12.1822"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1907"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.102005322.x"},{"key":"e_1_2_11_10_1","first-page":"1269","article-title":"A study of immunoglobulin G in the cerebrospinal fluid in multiple sclerosis and the log IgG\u2010index","volume":"113","author":"McLean BN","year":"1990","journal-title":"Brain"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.12.1537"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.180"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49038.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<831::AID-ANA21>3.0.CO;2-H"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.12.2625"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.1.133"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2004.01103.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2004.01103.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:43:03Z","timestamp":1696894983000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2004.01103.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,17]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1111\/j.1468-1331.2004.01103.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2004.01103.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,17]]},"assertion":[{"value":"2005-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}