{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:27:31Z","timestamp":1774085251375,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>At the present time, there are no proven beneficial effects of chemotherapy (CT) for the treatment of pure low\u2010grade astrocytomas. Brain radiotherapy (RT) still remains the standard treatment in order to reduce or delay tumor progression or symptoms, despite possible long\u2010term neurologic complications. We report 10 patients, with histologically proven pure low\u2010grade fibrillary astrocytomas, to which we administered a first\u2010line nitrosourea\u2010based CT. All patients were symptomatic with pharmaco\u2010resistant epilepsy or neurologic symptoms, and had been rejected for neurosurgical resection. All patients with epilepsy had a clinical improvement with reduction in seizure frequency and 60% became seizure\u2010free. CT was well tolerated; all patients developed myelosuppression with 40% of grade III\/IV hematotoxicity. Seven were alive at the time of writing with a mean follow\u2010up of 6.5\u2003years (3.5\u201312) from first recorded symptoms. The three deceased patients died 7.5, 7.5, and 8.5\u2003years from first symptoms. These results demonstrate that some patients with symptomatic non\u2010resectable fibrillary low\u2010grade astrocytomas can be treated with up\u2010front CT to improve their neurologic status. This report suggests that benefits of CT on symptoms, survival, and quality of life should be prospectively compared with RT.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2005.01028.x","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T15:54:41Z","timestamp":1125071681000},"page":"685-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["First\u2010line nitrosourea\u2010based chemotherapy in symptomatic non\u2010resectable supratentorial pure low\u2010grade astrocytomas"],"prefix":"10.1111","volume":"12","author":[{"given":"M. P.","family":"Frenay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Vandenbos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lebrun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg371"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1215\/S1152851702000431"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.7.1402"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.10.2013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.19.1473"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440207"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.4.0764"},{"key":"e_1_2_7_10_1","first-page":"1647","article-title":"Combination carmustine (BCNU) and dihydrogalactilol in the treatment of primary brain tumors recurring after irradiation","volume":"66","author":"Eagan RT","year":"1982","journal-title":"Cancer Treatment Reports"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.78.6.0909"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00048-4"},{"key":"e_1_2_7_13_1","first-page":"400a","article-title":"Immediate postoperative radiotherapy in low grade glioma improves progression free survival, but not overall survival: preliminary results of an EORTC\/MRC randomized phase III study","volume":"17","author":"Karim AB","year":"1998","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02692-X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.95.5.0735"},{"key":"e_1_2_7_16_1","volume-title":"Tumors of the Nervous System, Pathology and Genetic Classification of Tumors","author":"Kleihues P","year":"2000"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11398-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.82.3.0418"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.4.0665"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10359"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.203"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000012087"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.7.1442"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg502"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.3.291"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.10.1285"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-5-2-128"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2005.01028.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2005.01028.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:37:36Z","timestamp":1696901856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2005.01028.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,26]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1111\/j.1468-1331.2005.01028.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2005.01028.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,26]]},"assertion":[{"value":"2005-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}