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We examined the CSF, immunological and electrophysiological characteristics from a cohort of patients with Guillain\u2010Barr\u00e9 syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP), and from patients with other neurological diseases as control. Thirty\u2010eight percent of GBS patients and 28% of CIDP patients had detectable serum titers of anti\u2010ganglioside antibodies, which were associated with a high incidence of motor conduction block and increased F wave latencies. In GBS patients, but not in CIDP or control patients, there was an association between anti\u2010ganglioside antibodies and increased CSF immunoglobulin\u2010G (IgG) levels as determined by the IgG index. However, none of the GBS patients had CSF oligoclonal bands (OBs) or indications of intrathecal anti\u2010ganglioside antibody synthesis. The possibility of an abnormal CSF concentration of immunoglobulins from serum through dysfunctional BCB or damaged nerve roots, and the role of serum anti\u2010ganglioside reactivity in this process are discussed.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01161.x","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T13:31:20Z","timestamp":1140442280000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anti\u2010ganglioside antibodies and elevated CSF IgG levels in Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1111","volume":"13","author":[{"given":"S.","family":"Mat\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Amantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sorbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1975.tb05765.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.29.12.1105"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1986.tb03294.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.12_suppl_6.S7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf272"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296548"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310407"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160606"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200009)23:9<1414::AID-MUS13>3.0.CO;2-0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.7.1459"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1212\/WNL.41.5.617","article-title":"Research criteria for diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)","volume":"41","author":"Ad Hoc Subcommittee of the American Academy of Neurology AIDS Task Force.","year":"1991","journal-title":"Neurology"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92644-2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"issue":"28","key":"e_1_2_6_16_2","first-page":"1","article-title":"Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid. 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