{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:45:18Z","timestamp":1788561918699,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,7,31]],"date-time":"2006-07-31T00:00:00Z","timestamp":1154304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>Complex painful reflex syndrome is sometimes described in the chronic phase of stroke. Acute autonomic dysfunction (AAD), which is occasionally present in cases of acute stroke, has not been studied prospectively. The aim of the study was to investigate AAD on the hemibody contralateral to the lesion in the acute phase of stroke. One hundred consecutive patients (median age\u2003\u00b1\u2003interquartile range, 74\u2003\u00b1\u200321; range 19\u201393; 51 women: 80\u2003\u00b1\u200317 and 49 men: 70\u2003\u00b1\u200317\u2003years) in the acute phase of stroke were studied prospectively. Changes in skin temperature or coloration, diaphoresis, pain, or edema were noted in the first 3\u2003days post\u2010stroke. Associations between AAD and topography (cortical pre\u2010 and\/or post\u2010central, insular, corona radiata, basal ganglia, internal capsule, thalamus, and brainstem), age, gender, ischemic or hemorrhagic etiology, or the presence of sensorimotor deficits or ataxia were examined using the chi\u2010squared or Fisher's exact test and logistic regression analysis. AAD was found in 71% of the patients and showed a significant positive association with the presence of a lesion in the post\u2010central cortex (<jats:italic>P<\/jats:italic>\u2003=\u20030.037), internal capsule (<jats:italic>P<\/jats:italic>\u2003=\u20030.005), basal ganglia (<jats:italic>P<\/jats:italic>\u2003=\u20030.002), or insula (<jats:italic>P<\/jats:italic>\u2003=\u20030.011) and a negative association with the presence of a lesion in the brainstem (<jats:italic>P<\/jats:italic>\u2003=\u20030.004). Multivariate logistic regression analysis including all studied topographic variables showed that only brainstem lesions were significantly associated with a decreased risk of developing AAD (odds ratio\u2003=\u20030.08, 95% confidence interval: 0.01\u20130.69, <jats:italic>P<\/jats:italic>\u2003= 0.022). AAD was not associated with age, gender, the ischemic or hemorrhagic nature of the lesion, the side of lesion, hypertonic or hypotonic paresis, or hyperreflexia or hyporeflexia. AAD was found in association with sensory deficits (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) and contralateral hyperkinesia (<jats:italic>P<\/jats:italic>\u2003=\u20030.004). Acute AAD is significantly more likely to occur in the presence of hemispheric lesions involving sensory pathways from the cortex to the internal capsule and insula and is significantly less prevalent in the presence of brainstem lesions.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01488.x","type":"journal-article","created":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T19:37:34Z","timestamp":1154461054000},"page":"1245-1250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute autonomic dysfunction contralateral to acute strokes: a prospective study of 100 consecutive cases"],"prefix":"10.1111","volume":"13","author":[{"given":"K.","family":"Diserens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vuadens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reichhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. R.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bogousslavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ghika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00110-E"},{"key":"e_1_2_5_3_2","author":"Mitchell SW","year":"1864","journal-title":"Gunshot Wounds and Other Injuries of the Nerves"},{"key":"e_1_2_5_4_2","first-page":"780","article-title":"Reflex sympathetic dystrophy","volume":"26","author":"Evans JA","year":"1946","journal-title":"Surgical Clinics of North America"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199806000-00012"},{"key":"e_1_2_5_6_2","article-title":"Complex regional pain syndrome","author":"Harden RN","year":"2001","journal-title":"Progress in Pain Research and Management"},{"key":"e_1_2_5_7_2","volume-title":"Strata Statistical Software, Release 8.2","author":"Stata Corporation","year":"2003"},{"key":"e_1_2_5_8_2","first-page":"262","article-title":"Autonomic failure after stroke \u2013 is it indicative for pathophysiology of complex regional pain syndrome","volume":"101","author":"Riedl B","year":"2000","journal-title":"Acta Neurologica Scandinavica"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.101004262x.\/"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.9.684"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/154596830001400107"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-200201000-00006"},{"key":"e_1_2_5_13_2","first-page":"353","article-title":"Shoulder\u2010hand syndrome of a hemiplegic population: a 5\u2010year retrospective study","volume":"58","author":"Davis SW","year":"1977","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"key":"e_1_2_5_14_2","volume-title":"Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definition of Terms","author":"Merskey H","year":"1995"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1996.tb07076.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000038905.75660.BD"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.8.1379"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101404"},{"key":"e_1_2_5_19_2","first-page":"23","article-title":"Painful shoulder in hemiplegia","volume":"67","author":"Van Ouwenaller C","year":"1986","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","DOI":"10.1213\/00000539-193901000-00019","volume-title":"La Chirurgie de la Douleur","author":"Leriche R","year":"1939"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00003086-198808000-00015","article-title":"Reflex sympathetic dystrophy in cervical spinal cord injury patients","volume":"233","author":"Gellman H","year":"1988","journal-title":"Clin Orthop Relat Res."},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PHM.0000138739.18844.88"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2006.01488.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2006.01488.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:38:22Z","timestamp":1696912702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2006.01488.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,13]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1468-1331.2006.01488.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2006.01488.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,13]]},"assertion":[{"value":"2006-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}