{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:28:30Z","timestamp":1791160110923,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T00:00:00Z","timestamp":1163376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Neurotrophic effects of the growth hormone (GH), insulin\u2010like growth factor\u20101 (IGF\u20101) and insulin on the central nervous system have become more apparent in the past decade. In this study, we measured serum and cerebrospinal fluid (CSF) concentrations of GH, IGF\u20101 and insulin in 35 patients with motor neuron disease (MND) [24 patients with definite amyotrophic lateral sclerosis (ALS) and 11 patients with progressive bulbar palsy] and in 40 healthy controls. Levels of serum concentrations of GH and IGF\u20101 did not significantly differ between the MND patient group and the healthy controls, while the level of insulin was significantly decreased (<jats:italic>P<\/jats:italic>\u2003=\u20030.0033) in the MND patient group. However, levels of all three examined parameters in CSF were significantly lower in the MND group than in the healthy controls with the statistical significance for IGF\u20101 and insulin of <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001. This finding has not been reported previously, and further investigations into its association with ALS should establish whether it can be used as an early marker of the disease, or whether it merely represents a consequence of ALS development.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01503.x","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T18:04:51Z","timestamp":1163441091000},"page":"1340-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Comparison of the growth hormone, IGF\u20101 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls"],"prefix":"10.1111","volume":"13","author":[{"given":"E.","family":"Bilic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Rudan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kusec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zurak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Delimar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16634-8"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220261"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085764"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200407021"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199702)32:2<202::AID-NEU5>3.0.CO;2-C"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.04.011"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20451"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.03.002"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086071"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00801.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-7439(87)80084-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90193-6"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00402-C"},{"key":"e_1_2_7_16_2","first-page":"1","article-title":"Neural growth hormone","volume":"20","author":"Harvey S","year":"2003","journal-title":"Journal of Molecular Biosciences"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00223.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.1.7894"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90766-9"},{"key":"e_1_2_7_20_2","first-page":"2265","article-title":"IGF\u20101 enhances neurote regeneration but is not required for its survival in adult DRG explant","volume":"8","author":"Akahori Y","year":"1987","journal-title":"Neuro Report"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb09387.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90009-4"},{"key":"e_1_2_7_23_2","first-page":"161","article-title":"Growth hormone: neurocrine and neuroendocrine perspectives","volume":"3","author":"Harvey S","year":"1993","journal-title":"Growth Regulation"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070058"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"11672","DOI":"10.1016\/S0021-9258(20)71260-3","article-title":"Insulin binds to specific receptors and stimulates 2\u2010deoxyglucose uptake in cultured glial cells from rat brain","volume":"259","author":"Clarke DW","year":"1984","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb01824.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb09750.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.03.001"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1999.00536.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00040-3"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00681-7"},{"key":"e_1_2_7_32_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/cpt1971122part2360","article-title":"Glucose, insulin and free fatty acid metabolism in Parkinson's disease treated with levodopa","volume":"12","author":"Van Woert MH","year":"1971","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000212174"},{"key":"e_1_2_7_34_2","first-page":"20:255","article-title":"Pathophysiological implications of insulin resistance on vascular endothelial function","author":"Wheatcroft SB","year":"2003","journal-title":"Diabetic Medicine"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1984.tb00851.x"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(84)90154-0"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1999.12.2.113"},{"key":"e_1_2_7_38_2","first-page":"1312","article-title":"The presence of membrane fusion proteins in chorioid plexus epithelium","volume":"24","author":"Szmydynger\u2010Chodobska J","year":"1998","journal-title":"Abstracts: Society for Neuroscience"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01261-2"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2006.01503.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2006.01503.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:13:54Z","timestamp":1696911234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2006.01503.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,13]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1468-1331.2006.01503.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2006.01503.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,13]]},"assertion":[{"value":"2006-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}