{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T10:54:39Z","timestamp":1759056879314},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Intravenous immunoglobulin (IVIg) is an efficacious treatment for immune\u2010mediated neuropathies like Guillain\u2013Barr\u00e9 syndrome (GBS), chronic inflammatory demyelinating neuropathy (CIDP), and multifocal motor neuropathy (MMN). In the pathogenesis of immune\u2010mediated neuropathies chemokines and their receptors play a crucial role. Using flow cytometry we examined whether IVIg modulates chemokine expression repertoires of T cells and monocytes. The expression of inflammatory chemokine receptors CCR1, CCR2, CCR4, CCR5, CCR6 and CXCR3 was investigated on circulating T\u2010cell subsets, and CCR1, CCR2 and CCR5 on circulating monocytes before and after IVIg treatment in patients with immune\u2010mediated neuropathies (MMN, <jats:italic>n<\/jats:italic>\u2003=\u20037; GBS, <jats:italic>n<\/jats:italic>\u2003=\u20031; CIDP, <jats:italic>n<\/jats:italic>\u2003=\u20032). Furthermore, the homing potential of T cells was analyzed by the expression of CCR7, a chemokine receptor known to be utilized by mature T cells to recirculate into secondary lymphoid organs. In contrast to studies in chronic heart failure, no differences in expression patterns before and after IVIg treatment of any of the investigated chemokine receptors were found. Furthermore, the proportion of CD45RO\u2010positive CD4<jats:sup>+<\/jats:sup> or CD8<jats:sup>+<\/jats:sup> T\u2010cell subsets was not changed by IVIg treatment. Thus, we concluded that modulation of the expression of chemokine receptors on circulating leukocytes by IVIg is not a mode of action in immune\u2010mediated neuropathies.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01521.x","type":"journal-article","created":{"date-parts":[[2006,10,23]],"date-time":"2006-10-23T14:45:52Z","timestamp":1161614752000},"page":"1359-1363","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Expression of chemokine receptors on peripheral blood mononuclear cells of patients with immune\u2010mediated neuropathies treated with intravenous immunoglobulins"],"prefix":"10.1111","volume":"13","author":[{"given":"C.","family":"Trebst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Brunhorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Windhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stangel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.445"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.4.1067"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.1997.tb00027.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/344266"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1385\/IR:21:2-3:203"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-2023(02)00355-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.152"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00067.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/13550280390201001","article-title":"Expression of CCR2, CCR5, and CXCR3 by CD4+ T cells is stable during a 2\u2010year longitudinal study but varies widely between individuals","volume":"9","author":"Kivis\u00e4kk P","year":"2003","journal-title":"Journal of Neurovirology"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01335-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh518"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.09.020"},{"key":"e_1_2_6_14_2","first-page":"571","article-title":"Chemokines and chemokine receptors in inflammatory demyelinating neuropathies \u2013 a central role for IP\u201010","volume":"15","author":"Kieseier BC","year":"2002","journal-title":"Brain"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh297"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh343"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3624"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1994.1186"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.d01-904.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118488"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2006.01521.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2006.01521.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:14:19Z","timestamp":1696911259000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2006.01521.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,13]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1468-1331.2006.01521.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2006.01521.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,13]]},"assertion":[{"value":"2006-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}