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The most severe, potentially fatal disease caused by thiamine deficiency is the neurological disorder Wernicke\u2013Korsakoff syndrome. This can be difficult to diagnose and many cases remain undiagnosed. Treatment with thiamine generally results in a dramatic clinical improvement. Thiamine supplementation of stable food products like flour is an effective, simple and safe public health measure that can improve the thiamine status of all population groups.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01530.x","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T11:06:54Z","timestamp":1158750414000},"page":"1078-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Thiamine (vitamin B1) deficiency and associated brain damage is still common throughout the world and prevention is simple and safe!"],"prefix":"10.1111","volume":"13","author":[{"given":"C.","family":"Harper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,20]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524013363870"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.4.341"},{"key":"e_1_2_10_4_2","first-page":"153","article-title":"L'irm dans l'exploration de l'encephalopathie de gayet\u2010Wernicke","volume":"29","author":"Lenz V","year":"2002","journal-title":"Journal of Neuroradiology Journal de Neuroradiologie"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.1.1"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.7.593"},{"key":"e_1_2_10_7_2","first-page":"1866","article-title":"Putting thiamine in beer: comments on Truswell's editorial [comment]","volume":"95","author":"Thomson AD","year":"2000","journal-title":"Addiction"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000008226"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/34.6.862"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.alcalc.a008284"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.alcalc.a008268"},{"key":"e_1_2_10_12_2","first-page":"1743","article-title":"Anaphylaxis to parenteral thiamine (vitamin b1)","volume":"128","author":"Morinville V","year":"1998","journal-title":"Schweizerische Medizinische Wochenschrift Journal Suisse de Medecine"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1980.tb03720.x"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.21337"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01603-9"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(99)80019-3"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(200012)28:4<451::AID-EAT14>3.0.CO;2-I"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2000.0138"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(00)00325-7"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.28578"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.911.582"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(98)00153-2"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.6.808"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.1999.1037"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2000.tb01268.x"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/29.2.111"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.70.2.54"},{"key":"e_1_2_10_28_2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/jn\/129.2.366","article-title":"Thiamine deficiency is prevalent in a selected group of urban Indonesian elderly people","volume":"129","author":"Andrade Juguan J","year":"1999","journal-title":"Journal of Nutrition"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06316-8"},{"key":"e_1_2_10_30_2","first-page":"156","article-title":"Flour enrichment around the world","volume":"4","author":"Axford DWE","year":"1981","journal-title":"British Flour Milling and Baking Research Association"},{"key":"e_1_2_10_31_2","volume-title":"Nutrification of Food","author":"Bauerfeind JC","year":"1988"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.3.226"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.2.282"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/09595238280000481"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1979.tb112099.x"},{"key":"e_1_2_10_36_2","first-page":"115","volume-title":"Quick Reference to Clinical Nutrition. 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