{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:39:14Z","timestamp":1792683554807,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T00:00:00Z","timestamp":1161734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>There is paucity of studies on predictors of long\u2010term sequelae of tuberculous meningitis (TBM). We report the neurological sequelae of TBM at 1\u2003year and their predictors. Patients with TBM who were followed up for 1\u2003year were included. The diagnosis of TBM was based on clinical, cerebrospinal fluid (CSF) and computed tomography (CT) scan findings. Detailed neurological examinations at admission and at 1\u2003year were carried out. All the patients received four\u2010drug antitubercular therapy. The frequency of sequelae at 1\u2003year were noted and the role of various demographic (age, sex, duration of illness, BCG vaccination), clinical (weakness, seizure, extra central nervous system tuberculosis, Glasgow Coma Scale (GCS) score, cranial nerve palsy, stage, corticosteroid, drug\u2010induced hepatitis, shunt surgery), and laboratory findings (erythrocyte sedimentation rate (ESR), CSF cell and protein, CT scan evidences of hydrocephalus, basal exudates, infarctions and tuberculoma) at presentation were evaluated employing logistic regression analysis. Sixty\u2010five patients with TBM were included in this study whose age ranged between 13 and 80\u2003years (mean 33.2), 27 of whom were females. Complete neurological recovery at 1\u2003year occurred in 21.5% patients only although about 50% were independent for activities of daily living. Neurological sequelae were observed in 78.5% patients, which included cognitive impairment in 55%, motor deficit in 40%, optic atrophy in 37% and other cranial nerve palsy in 23%. On logistic regression analysis, focal motor deficit at admission was the most important predictor of neurologic deficits at 1\u2003year. GCS score predicted the cognitive and motor sequelae. Neurological sequelae at year occurred in 78.5% patients with TBM in the form of cognitive impairment, motor deficit and optic atrophy. Sequelae were common in patients who had focal motor deficit and altered sensorium at admission.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01534.x","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T15:36:59Z","timestamp":1161790619000},"page":"33-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Predictors of long\u2010term neurological sequelae of tuberculous meningitis: a multivariate analysis"],"prefix":"10.1111","volume":"14","author":[{"given":"J.","family":"Kalita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. K.","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(90)90069-K"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80066-7"},{"key":"e_1_2_7_4_2","first-page":"281","article-title":"Prognosis and sequelae of tuberculous meningitis in adults","volume":"18","author":"Gulati PD","year":"1970","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540050164209"},{"key":"e_1_2_7_6_2","first-page":"215","article-title":"Prognosis of tuberculous meningitis in adults in the era of modern antituberculous chemotherapy","volume":"35","author":"Wang JT","year":"2002","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"e_1_2_7_7_2","first-page":"106","article-title":"A retrospective survey of proven cases of tuberculous meningitis in the Northern Region, 1970\u20131980","volume":"17","author":"Bateman DE","year":"1983","journal-title":"Journal of the Royal College of Physicians of London"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-196710000-00008"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.6.987"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-001-1100-3"},{"key":"e_1_2_7_11_2","first-page":"261","article-title":"Outcome of tuberculous meningitis at 6 and 12,months: a multivariate regression analysis","volume":"3","author":"Kalita J","year":"1999","journal-title":"The International Journal of Tuberculosis and Lung Disease"},{"key":"e_1_2_7_12_2","first-page":"83","article-title":"Prognostic indicators in patients with intracranial tuberculoma: a review of 102 cases","volume":"54","author":"Wasay M","year":"2004","journal-title":"The Journal of the Pakistan Medical Association"},{"key":"e_1_2_7_13_2","first-page":"159","article-title":"Predictors of inpatient mortality in 190 adult patients with tuberculous meningitis","volume":"52","author":"Qureshi HU","year":"2002","journal-title":"The Journal of the Pakistan Medical Association"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-001-2014-9"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.3.300"},{"key":"e_1_2_7_16_2","first-page":"64","article-title":"Predictors of outcome in patients with tuberculous meningitis","volume":"6","author":"Hosoglu S","year":"2002","journal-title":"The International Journal of Tuberculosis and Lung Disease"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(60)80132-1"},{"key":"e_1_2_7_18_2","first-page":"61","article-title":"Functional evaluation: the Barthel index","volume":"14","author":"Mahony FI","year":"1967","journal-title":"Maryland State Medical Journal"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500180078038"},{"key":"e_1_2_7_20_2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/oxfordjournals.aje.a114444","article-title":"A programme logistic regression in IBM PC","volume":"124","author":"Mc Gee DI","year":"1980","journal-title":"American Journal of Epidemiology"},{"key":"e_1_2_7_21_2","first-page":"13","article-title":"The results of treatment of 549 cases of tuberculous meningitis","volume":"69","author":"Lorber J","year":"1954","journal-title":"American Review of Tuberculosis"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.137.11.1518"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198707000-00004"},{"key":"e_1_2_7_24_2","first-page":"34","article-title":"Late neurologic sequelae of tuberculous meningitis","volume":"51","author":"Donner M","year":"1962","journal-title":"Acta Paediatrica"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-3879(56)80059-7"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.39.205.213"},{"key":"e_1_2_7_27_2","first-page":"823","article-title":"US Veterans administration \u2013 armed forces comparative study on the chemotherapy of tuberculosis XIII. Tuberculous meningitis in adults, with special reference to survival, neurologic residuals, and work status","volume":"91","author":"Falk A","year":"1962","journal-title":"The American Review of Respiratory Disease"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(56)91768-8"},{"key":"e_1_2_7_29_2","first-page":"43","article-title":"Late ophthalmological sequelae of tuberculous meningitis","volume":"51","author":"Miettinen P","year":"1962","journal-title":"Acta Paediatrica"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(71)90222-X"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050147"},{"key":"e_1_2_7_32_2","first-page":"455","article-title":"Effectiveness of BCG vaccination against tuberculous meningitis","volume":"36","author":"Awasthi S","year":"1999","journal-title":"Indian Pediatrics"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0692"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(55)90003-9"},{"key":"e_1_2_7_35_2","first-page":"267","article-title":"Effect of methyl prednisolone on sensory motor functions in tuberculous meningitis","volume":"49","author":"Kalita J","year":"2001","journal-title":"Neurology India"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.2.226"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2006.01534.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2006.01534.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:08:03Z","timestamp":1696885683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2006.01534.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1468-1331.2006.01534.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2006.01534.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2007-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}