{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:47:53Z","timestamp":1696942073904},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>The insula of Reil constitutes a functionally intriguing complex of the brain related to multifunctional activities. We examined the subinsular region in 119 consecutively autopsied patients, as T2 hyperintense lesions are frequently observed in magnetic resonance diagnosis of this region. The patients were admitted in neurology wards and were diagnosed as having cerebrovascular disease in 55 patients (46%), other neurological diseases in 57 patients (48%) and non\u2010neurological diseases in seven patients (6%). Demyelination of the white matter was semi\u2010quantified as a fiber density score (percent stained area\/total area) with computer\u2010assisted image analysis on Kl\u00fcver\u2013Barrera\u2010stained sections. Astrogliosis was assessed by immunohistochemistry for glial fibrillary acidic protein.<\/jats:p><jats:p>The lesion analysis showed a dilated perivascular space in 29 patients (24%), demyelination (fiber density score less than the mean\u2003\u2212\u20031 SD) in 27 patients (23%), slit\u2010shaped lesion in six patients (5%), lacunar infarction in one patient (1%) and cerebral hemorrhage in one patient (1%). A histologic\u2013radiologic comparison in two patients with subcortical ischemic vascular dementia showed correspondence between subinsular hyperintensities, and demyelination, gliosis and a dilated perivascular space. These results indicate that subinsular lesions rarely signifies focal vascular lesions, and are consisted of demyelination, gliosis and a dilated perivascular space.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01567.x","type":"journal-article","created":{"date-parts":[[2006,10,23]],"date-time":"2006-10-23T14:45:52Z","timestamp":1161614752000},"page":"95-101","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Subinsular vascular lesions: an analysis of 119 consecutive autopsied 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