{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:06:46Z","timestamp":1761894406617},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>The aim of this study was to investigate the changes in cerebral blood flow velocity (CBFV) and its relation to apolipoprotein E (apoE) <jats:italic>\u025b<\/jats:italic>4 allele in mild cognitive impairment (MCI). Thirty MCI and 30 controls were assessed using Mini\u2010Mental State Examination (MMSE) and Cambridge Cognitive Examination\u2010Chinese version (CAMCOG\u2010C), and then insonated in the anterior (ACA), middle (MCA) and basilar (BA) cerebral arteries using transcranial Doppler ultrasonography. Compared with controls, MCI showed significant decreases in the mean (<jats:italic>V<\/jats:italic><jats:sub>m<\/jats:sub>), systolic (<jats:italic>V<\/jats:italic><jats:sub>s<\/jats:sub>) and diastolic (<jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>) CBFV, bilaterally in MCA and ACA (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05\u20130.001), but not in BA. Compared with 17 apoE <jats:italic>\u025b<\/jats:italic>4 allele non\u2010carriers, 13 carriers in MCI showed significant CBFV decreases, bilaterally in MCA (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05\u20130.001). Our findings, the decreased CBFV in apoE <jats:italic>\u025b<\/jats:italic>4 allele carriers with MCI, suggest that a large sample and longitudinal study in CBFV and cognitive changes may have the implications on early diagnosis of Alzheimer's disease.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01579.x","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T19:53:01Z","timestamp":1162497181000},"page":"150-155","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Decreased cerebral blood flow velocity in apolipoprotein E <i>\u025b<\/i>4 allele carriers with mild cognitive 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