{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:01:22Z","timestamp":1791907282422,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T00:00:00Z","timestamp":1169510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>The aim of the present study was the quantitation of total tau protein (<jats:italic>\u03c4<\/jats:italic><jats:sub>T<\/jats:sub>), tau phosphorylated at threonine 181 (<jats:italic>\u03c4<\/jats:italic><jats:sub>P\u2010181<\/jats:sub>) and <jats:italic>\u03b2<\/jats:italic>\u2010amyloid<jats:sub>1\u221242<\/jats:sub> (A<jats:italic>\u03b2<\/jats:italic>42) in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD) and controls. Double sandwich ELISAs (Innogenetics) were used for the measurements. Total tau was significantly increased in iNPH and highly increased in AD as compared with the control group, whilst A<jats:italic>\u03b2<\/jats:italic>42 was decreased in both diseases. CSF <jats:italic>\u03c4<\/jats:italic><jats:sub>P\u2212181<\/jats:sub> levels were significantly increased only in AD, but not in iNPH as compared with the controls. A cut\u2010off level for <jats:italic>\u03c4<\/jats:italic><jats:sub>T<\/jats:sub> at 300\u2003pg\/ml, successfully discriminated AD from normal aging with a 95.8% specificity and 91% sensitivity; whilst the <jats:italic>\u03c4<\/jats:italic><jats:sub>P\u2010181<\/jats:sub>\/<jats:italic>\u03c4<\/jats:italic><jats:sub>T<\/jats:sub> ratio (cut\u2010off value 0.169) was more specific (100%) but less sensitive (92.5%). For the discrimination of iNPH from AD <jats:italic>\u03c4<\/jats:italic><jats:sub>T<\/jats:sub> achieved low specificity (77.8%) but high sensitivity (92.5%), whilst <jats:italic>\u03c4<\/jats:italic><jats:sub>P\u2010181<\/jats:sub> (cut\u2010off value 47.4) was both sensitive and specific (88.7% and 86.7% respectively) for the discrimination of these disorders. The present study, despite being clinical, supports the notion that CSF <jats:italic>\u03c4<\/jats:italic><jats:sub>P\u2010181<\/jats:sub> alone or in combination with <jats:italic>\u03c4<\/jats:italic><jats:sub>T<\/jats:sub> may be a useful marker in the discrimination of iNPH from AD.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01593.x","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T09:31:07Z","timestamp":1169544667000},"page":"168-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Cerebrospinal fluid tau, phospho\u2010tau<sub>181<\/sub> and <i>\u03b2<\/i>\u2010amyloid<sub>1\u221242<\/sub> in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease"],"prefix":"10.1111","volume":"14","author":[{"given":"E. N.","family":"Kapaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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