{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:22:30Z","timestamp":1791912150847,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T00:00:00Z","timestamp":1169510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Chronic headaches are difficult to treat and represent the biggest challenge in headache centres. Mirtazapine has a prophylactic and ibuprofen an acute effect in tension\u2010type headache. Combination therapy may increase efficacy and lower side effects. We aimed to evaluate the prophylactic effect of a combination of low\u2010dose mirtazapine and ibuprofen in chronic tension\u2010type headache. Ninety\u2010three patients were included in the double\u2010blind, placebo\u2010controlled, parallel trial. Following a 4\u2010week run\u2010in period they were randomized to four groups for treatment with a combination of mirtazapine 4.5\u2003mg and ibuprofen 400\u2003mg, placebo, mirtazapine 4.5\u2003mg or ibuprofen 400\u2003mg daily for 8\u2003weeks. Eighty\u2010four patients completed the study. The primary efficacy parameter, change in area under the headache curve from run\u2010in to the last 4\u2003weeks of treatment, did not differ between combination therapy (190) and placebo (219), <jats:italic>P<\/jats:italic>\u2003= 0.85. Explanatory analyses revealed worsening of headache already in the third week of treatment with ibuprofen alone. In conclusion, the combination of low\u2010dose mirtazapine and ibuprofen is not effective for the treatment of chronic tension\u2010type headache. Moreover, the study suggests that daily intake of ibuprofen worsens headache already after few weeks in chronic tension\u2010type headache.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2006.01607.x","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T09:31:07Z","timestamp":1169544667000},"page":"187-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Combination of low\u2010dose mirtazapine and ibuprofen for prophylaxis of chronic tension\u2010type headache"],"prefix":"10.1111","volume":"14","author":[{"given":"L.","family":"Bendtsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Buchgreitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ashina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.09.026"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00941.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-002-0083-9"},{"key":"e_1_2_6_5_2","first-page":"735","volume-title":"The Headaches","author":"Bendtsen L","year":"2005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00825-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.09.012"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000127282.90920.8C"},{"issue":"17","key":"e_1_2_6_10_2","first-page":"4","article-title":"Pharmacology of antidepressants: selectivity or multiplicity","volume":"60","author":"Westenberg HG","year":"1999","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957040-00010"},{"key":"e_1_2_6_12_2","first-page":"727","volume-title":"The Headaches","author":"Mathew NT","year":"2005"},{"key":"e_1_2_6_13_2","first-page":"553","volume-title":"The Headaches","author":"Evers S","year":"2005"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1992.00369.x"},{"issue":"7","key":"e_1_2_6_15_2","first-page":"1","article-title":"Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain","volume":"8","author":"Headache Classification Committee of the International Headache Society","year":"1988","journal-title":"Cephalalgia"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_2_6_17_2","first-page":"1","volume-title":"Practical Statistics for Medical Research","author":"Altman DG","year":"1991"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063322.14078.90"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00824-5"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10654-004-6519-2","article-title":"Has the prevalence of migraine and tension\u2010type headache changed over a 12\u2010year period? A Danish population survey","volume":"20","author":"Lyngberg AC","year":"2005","journal-title":"European Journal of Epidemiology"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2006.01607.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2006.01607.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:39:42Z","timestamp":1696883982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2006.01607.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,23]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1468-1331.2006.01607.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2006.01607.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,23]]},"assertion":[{"value":"2007-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}