{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T10:50:55Z","timestamp":1750071055370},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>Bilateral temporo\u2010parietal hypoperfusion and decreased glucose metabolism are characteristic <jats:italic>in vivo<\/jats:italic> findings in Alzheimer\u2019s disease (AD). Lactate is a metabolic vasodilator and is known to induce increased cerebral blood flow in healthy adults. The present study addresses the issue whether sodium lactate infusion affects functional state and resulting electroencephalographic patterns of AD patients. Twelve late\u2010onset sporadic AD probands participated in this self\u2010control study. The relative power and synchronization likelihood (SL) values of the electroencephalographic samples were calculated and compared off\u2010line before and after sodium lactate infusion (0.5\u2003<jats:sc>m<\/jats:sc>, 5\u2003ml\/kg body weight). Based on the reactivity to sodium lactate the scalp could be divided into three parts; no significant changes were seen in the seriously damaged (P3\u2013P4) areas. The moderately affected regions in the close neighborhood showed a paradoxic inactivation with electroencephalographic slowing, a likely consequence of the metabolic\u2010like steal effect of the near\u2010normal areas outside. These results indicate a diminished vascular and\/or metabolic reserve capacity to sodium lactate challenge in AD and confirm the formerly described electroencephalographic abnormalities.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2007.02016.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T09:52:38Z","timestamp":1284544358000},"page":"150-155","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer\u2019s disease patients\u2019 brain regions"],"prefix":"10.1111","volume":"15","author":[{"given":"A.","family":"J\u00e1rd\u00e1nh\u00e1zy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"J\u00e1rd\u00e1nh\u00e1zy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"K\u00e1lm\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,21]]},"reference":[{"issue":"4","key":"e_1_2_6_2_2","first-page":"91","article-title":"Ultrasctructural features of the neurovascular unit in Alzheimer\u2019s neurodegeneration","volume":"57","author":"Frontczak\u2010Baniewicz M","year":"2006","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X130371"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.4.611"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(98)90048-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(96)00033-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050383"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1379.012"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000106629"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(97)83777-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.01.001"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.2.137"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(03)00085-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.12.019"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-2789(01)00386-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(02)00041-7"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200212000-00010"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.02067.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.12.029"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.09.022"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(89)90064-3"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90876-1"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.4.442"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810060013003"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03924.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-198801000-00001"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.12.002"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj127"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1379.008"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900014164"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.06.045"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-006-0579-2"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01736-9"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.01.004"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-11803"},{"issue":"4","key":"e_1_2_6_36_2","first-page":"165","article-title":"The influence of acute progressive hypoxia on bioelectrical activity of the brain","volume":"57","author":"Jernajczyk W","year":"2006","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.04.001"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.03.009"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-1331.2007.02016.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-1331.2007.02016.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:31:21Z","timestamp":1696901481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-1331.2007.02016.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,21]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1468-1331.2007.02016.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-1331.2007.02016.x","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,21]]},"assertion":[{"value":"2008-01-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}