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This study aimed to investigate the 1\u2003year prevalence of headache in MS compared with the general population.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Population\u2010based case\u2013control study in Germany.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We included 491 patients with definite MS (68% female, mean age 45.3\u2003years, 63.7% relapsing remitting MS, mean Expanded Disability Status Scale (EDSS) 3.2, 106 treated with interferon\u2010\u03b2, 53 with glatiramer acetate, 271 untreated) and 447 age and gender matched controls. Headache was diagnosed with a validated questionnaire according to the International Headache Society Criteria. Headache prevalence was 56.2% (tension type headache 37.2%, migraine 24.6%). Headache prevalence rates did not differ from controls. Headache was not associated with disability or treatment. Trigeminal neuralgia was found in 6.3% of MS cases.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Results suggest that headache in MS patients reflects comorbidity in most conditions.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2008.02406.x","type":"journal-article","created":{"date-parts":[[2008,12,10]],"date-time":"2008-12-10T00:13:52Z","timestamp":1228868032000},"page":"262-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Prevalence of migraine, tension\u2010type headache and trigeminal neuralgia in multiple sclerosis"],"prefix":"10.1111","volume":"16","author":[{"given":"N.","family":"Putzki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pfriem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Limmroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6.","family":"Yaldizli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Tettenborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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