{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:23:45Z","timestamp":1761197025780},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T00:00:00Z","timestamp":1301270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Cardiac <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine (<jats:sup>123<\/jats:sup>I\u2010MIBG) uptake in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is markedly reduced, as in Parkinson\u2019s disease (PD).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We performed <jats:sup>123<\/jats:sup>I\u2010MIBG scintigrams on patients with iRBD and PD. After the initial <jats:sup>123<\/jats:sup>I\u2010MIBG scintigram, we retested subjects after a mean of 2.8\u2003years.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The delayed heart\u2010to\u2010mediastinum (H\/M) ratio of cardiac <jats:sup>123<\/jats:sup>I\u2010MIBG uptake was not significantly reduced between the first and second study in either group (<jats:italic>P<\/jats:italic>\u2003=\u20030.050, <jats:italic>P<\/jats:italic>\u2003=\u20030.091, respectively)<jats:bold>.<\/jats:bold> Follow\u2010up imaging revealed a mean decline of 4.21\u2003\u00b1\u20039.06% or 6.40\u2003\u00b1\u200319.02% in the delayed H\/M ratio in those with iRBD or PD, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The <jats:sup>123<\/jats:sup>I\u2010MIBG uptake findings might indicate progression early in the course of iRBD or PD, but the progression is heterogeneous and independent of development of motor symptoms.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2011.03392.x","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T03:33:29Z","timestamp":1301369609000},"page":"1275-1278","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Follow\u2010up study of cardiac <sup>123<\/sup>I\u2010MIBG scintigraphy in idiopathic REM sleep behavior disorder"],"prefix":"10.1111","volume":"18","author":[{"given":"T.","family":"Miyamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Iwanami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-160797-7\/50082-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000249313.25627.2e"},{"key":"e_1_2_7_4_2","volume-title":"International Classification of Sleep Disorders, 2nd edn. 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