{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:11:54Z","timestamp":1792375914194,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T00:00:00Z","timestamp":1311033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>Background and purposes:\u2002<\/jats:bold> Anti\u2010aquaporin 4 antibodies are specific markers for Devic\u2018s disease. This study aimed to test if this high specificity holds in the context of a large spectrum of systemic autoimmune and non\u2010autoimmune diseases.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Anti\u2010aquaporin\u20104 antibodies (NMO\u2010IgG) were determined by indirect immunofluorescence (IIF) on mouse cerebellum in 673 samples, as follows: group I (clinically defined Devic\u2019s disease, <jats:italic>n<\/jats:italic>\u2003=\u200347); group II [inflammatory\/demyelinating central nervous system (CNS) diseases, <jats:italic>n<\/jats:italic>\u2003=\u200341]; group III (systemic and organ\u2010specific autoimmune diseases, <jats:italic>n<\/jats:italic>\u2003=\u2003250); group IV (chronic or acute viral diseases, <jats:italic>n<\/jats:italic>\u2003=\u200335); and group V (randomly selected samples from a general clinical laboratory, <jats:italic>n<\/jats:italic>\u2003=\u2003300).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> MNO\u2010IgG was present in 40\/47 patients with classic Devic\u2019s disease (85.1% sensitivity) and in 13\/22 (59.1%) patients with disorders related to Devic\u2019s disease. The latter 13 positive samples had diagnosis of longitudinally extensive transverse myelitis (<jats:italic>n<\/jats:italic>\u2003=\u200310) and isolated idiopathic optic neuritis (<jats:italic>n<\/jats:italic>\u2003=\u20033). One patient with multiple sclerosis and none of the remaining 602 samples with autoimmune and miscellaneous diseases presented NMO\u2010IgG (99.8% specificity). The autoimmune disease subset included five systemic lupus erythematosus individuals with isolated or combined optic neuritis and myelitis and four primary Sj\u00f6gren\u2019s syndrome (SS) patients with cranial\/peripheral neuropathy.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The available data clearly point to the high specificity of anti\u2010aquaporin\u20104 antibodies for Devic\u2019s disease and related syndromes also in the context of miscellaneous non\u2010neurologic autoimmune and non\u2010autoimmune disorders.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2011.03479.x","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T20:10:34Z","timestamp":1311106234000},"page":"248-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Anti\u2010aquaporin\u20104 antibodies in the context of assorted immune\u2010mediated diseases"],"prefix":"10.1111","volume":"19","author":[{"given":"A.","family":"Dellavance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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