{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:22:50Z","timestamp":1789982570633,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Epidemiological and clinical studies show higher prevalence of amyotrophic lateral sclerosis (ALS) in males than in females and more severe lesions in androgen receptor (AR)\u2010expressing tissues. The <jats:italic>AR<\/jats:italic> gene contains a polymorphic CAG trinucleotide repeat, whose expansion over a certain threshold is toxic to motor neurons, causing spinal and bulbar muscular atrophy (SBMA).<\/jats:p><jats:p><jats:bold>Purpose and methods:\u2002<\/jats:bold> We tested the hypothesis that the <jats:italic>AR<\/jats:italic> CAG repeat linked to SBMA is a risk factor for ALS. We analyzed <jats:italic>AR<\/jats:italic> CAG expansions in 336 patients with ALS and 100 controls.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We found a negative association of <jats:italic>AR<\/jats:italic> CAG expansions with ALS susceptibility, clinical presentation, and survival.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our findings do not support a role of the <jats:italic>AR<\/jats:italic> CAG repeat length in ALS.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2011.03646.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T16:01:27Z","timestamp":1326211287000},"page":"1373-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CAG repeat length in androgen receptor gene is not associated with amyotrophic lateral sclerosis"],"prefix":"10.1111","volume":"19","author":[{"given":"A.","family":"Bruson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sambataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Querin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gaiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Galbiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pennuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pegoraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Soraru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1971"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152710791556096"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0195-y"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/17482961003610853"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1980.00500520027002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.867053"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2011.06.003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2004.03.001"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/352077a0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.2.568"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320550125"},{"key":"e_1_2_7_14_2","first-page":"96","article-title":"El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. 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