{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T17:38:23Z","timestamp":1794591503582,"version":"4.9.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T00:00:00Z","timestamp":1332720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To examine whether thrombolysis for stroke attributable to cervical artery dissection (CeAD<jats:sub>Stroke<\/jats:sub>) affects outcome and major haemorrhage rates.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We used a multicentre CeAD<jats:sub>Stroke<\/jats:sub> database to compare CeAD<jats:sub>Stroke<\/jats:sub> patients treated with and without thrombolysis. Main outcome measures were favourable 3\u2010month outcome (modified Rankin Scale 0\u20132) and \u2018major haemorrhage\u2019 [any intracranial haemorrhage (ICH) and major extracranial haemorrhage]. Adjusted odds ratios [OR (95% confidence intervals)] were calculated on the whole database and on propensity\u2010matched groups.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Among 616 CeAD<jats:sub>Stroke<\/jats:sub> patients, 68 (11.0%) received thrombolysis; which was used in 55 (81%) intravenously. Thrombolyzed patients had more severe strokes (median NIHSS score 16 vs. 3; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and more often occlusion of the dissected artery (66.2% vs. 39.4%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). After adjustment for stroke severity and vessel occlusion, the likelihood for favourable outcome did not differ between the treatment groups [OR<jats:sub>adjusted<\/jats:sub> 0.95 (95% CI 0.45\u20132.00)]. The propensity matching score model showed that the odds to recover favourably were virtually identical for 64 thrombolyzed and 64 non\u2010thrombolyzed\u2010matched CeAD<jats:sub>Stroke<\/jats:sub> patients [OR 1.00 (0.49\u20132.00)]. Haemorrhages occurred in 4 (5.9%) thrombolyzed patients, all being asymptomatic ICHs. In the non\u2010thrombolysis group, 3 (0.6%) patients had major haemorrhages [asymptomatic ICH (<jats:italic>n<\/jats:italic>\u2003=\u20032) and major extracranial haemorrhage (<jats:italic>n<\/jats:italic>\u2003=\u20031)].<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> As thrombolysis was neither independently associated with unfavourable outcome nor with an excess of symptomatic bleedings, our findings suggest thrombolysis should not be withheld in CeAD<jats:sub>Stroke<\/jats:sub> patients. However, the lack of any trend towards a benefit of thrombolysis may indicate the legitimacy to search for more efficient treatment options including mechanical revascularization strategies.<\/jats:p>","DOI":"10.1111\/j.1468-1331.2012.03704.x","type":"journal-article","created":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T20:06:45Z","timestamp":1332792405000},"page":"1199-1206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Thrombolysis in Cervical Artery Dissection \u2013 Data from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) database"],"prefix":"10.1111","volume":"19","author":[{"given":"S. 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